Study type
Vaccine studies recruiting now
Vaccine trials test how well new or updated vaccines produce an immune response and how they are tolerated. Many recruit healthy adults; some focus on older adults, children or people with specific conditions.
115 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingHealthy volunteersPhase 3
A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age
GlaxoSmithKline
- Location
- Mobile, AL + 46 other US sites
- Eligibility basics
- Ages 1–1
- RecruitingHealthy volunteersPhase 3
A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine and a Marketed Measles, Mumps and Rubella Vaccine When Administered as Intramuscular Injection to Healthy Children 12 to 15 Months of Age
GlaxoSmithKline
- Location
- Tucson, AZ + 12 other US sites
- Eligibility basics
- Ages 1–1
- RecruitingHealthy volunteersPhase 2
A Study to Learn About mRNA Vaccines Against Influenza in Adults
Pfizer
- Location
- Mobile, AL + 14 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 3
A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine
Pfizer
- Location
- Worcester, MA + 10 other US sites
- Eligibility basics
- Ages 7+
- RecruitingHealthy volunteersPhase 4
A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Vaccine Formulations
ModernaTX, Inc.
- Location
- Atlanta, GA + 5 other US sites
- Eligibility basics
- Ages 6 mo+
- RecruitingHealthy volunteersPhase 2
Safety, and Efficacy Study of ShigETEC, a Live, Attenuated, Oral Combination Vaccine to Prevent Shigella and ETEC Disease Delivered to Healthy Adults Ages 18 to 50 Years Old
Eveliqure Biotechnologies GmbH
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–50
- RecruitingPhase 3
A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocompromised Adults
Pfizer
- Location
- Los Angeles, CA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Personalized Neoantigen Vaccine Plus IL-12 (INO-9012) Versus Active Surveillance in Subjects With High-Risk HCC
Geneos Therapeutics
- Location
- New Orleans, LA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Scottsdale, AZ + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Participants With Mild Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Encino, CA + 3 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
GlaxoSmithKline
- Location
- Anniston, AL + 11 other US sites
- Eligibility basics
- Ages 65–85
- RecruitingPhase 3
Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease
Sanofi
- Location
- Atlanta, GA + 4 other US sites
- Eligibility basics
- Ages 2–17
- RecruitingHealthy volunteers
Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH)
National Institute of Environmental Health Sciences (NIEHS)
- Location
- Research Triangle Park, NC
- Eligibility basics
- Ages 18–100 · Women only
- RecruitingHealthy volunteersPhase 2
CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant
City of Hope Medical Center
- Location
- Duarte, CA + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 2
BPL-1357 Against H1N1 Influenza Virus Challenge
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteers
Sleep and Adolescent Vaccine Immunogenicity Pilot/Observational Study
Children's Hospital Medical Center, Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 11–12
- RecruitingHealthy volunteers
VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–120
- RecruitingHealthy volunteers
Screening Volunteers for Clinical Trials
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteers
Effect of Messaging on Pragmatic Outcomes Within an Integrated Healthcare System
Kaiser Permanente
- Location
- Pasadena, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 2
A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With Neuroblastoma
Memorial Sloan Kettering Cancer Center
- Location
- New York, NY
- Eligibility basics
- Any age listed
- RecruitingHealthy volunteers
Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
Lake Erie College of Osteopathic Medicine
- Location
- Erie, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Screening for LID Clinical Studies Unit Healthy Volunteer Protocols
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Interpersonal Communication Training and Vaccination Workflow Training Alone and in Combination to Improve Communication and Recommendations About HPV Vaccination in Pharmacies, IMPACT HPV Trial
Fred Hutchinson Cancer Center
- Location
- Seattle, WA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 4
Comparing Immune Response of 2 vs 3 HPV Doses (27-45 Years Old)
The University of Texas Medical Branch, Galveston
- Location
- Galveston, TX
- Eligibility basics
- Ages 27–45 · Women only
Who these studies look for
Vaccine studies often exclude people who recently received a related vaccine or had the infection, and those with conditions or medicines that affect the immune system.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Could I receive a placebo?
Often yes. Many vaccine trials are randomized, so some participants receive a comparison vaccine or placebo. The consent document explains this.