Study type
Vaccine studies recruiting now
Vaccine trials test how well new or updated vaccines produce an immune response and how they are tolerated. Many recruit healthy adults; some focus on older adults, children or people with specific conditions.
115 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Atlanta, GA + 6 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine
The Methodist Hospital Research Institute
- Location
- Houston, TX
- Eligibility basics
- Ages 65–100
- RecruitingHealthy volunteersPhase 1
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Location
- Birmingham, AL + 1 other US site
- Eligibility basics
- Ages 19+ · Women only
- RecruitingHealthy volunteersPhase 1
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Clinical Trials of Multivalent Opioid Vaccine Components
New York State Psychiatric Institute
- Location
- Eatontown, NJ
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Immunogenicity of Yellow Fever Vaccine 17D in Adults With Prior 17D Vaccination
Oregon Health and Science University
- Location
- Portland, OR
- Eligibility basics
- Ages 20–49
- RecruitingHealthy volunteersEarly Phase 1
Intradermal Influenza Vaccination
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteersPhase 3
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
Pfizer
- Location
- Birmingham, AL + 101 other US sites
- Eligibility basics
- Ages 1 mo–7 mo
- RecruitingHealthy volunteersPhase 4
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
Sanofi
- Location
- Fair Oaks, CA + 19 other US sites
- Eligibility basics
- Ages 12+
- RecruitingHealthy volunteersPhase 3
A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose
Pfizer
- Location
- Birmingham, AL + 76 other US sites
- Eligibility basics
- Ages 0 mo+
- RecruitingHealthy volunteersPhase 3
A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults
Pfizer
- Location
- Birmingham, AL + 36 other US sites
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersPhase 3
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
Pfizer
- Location
- Athens, AL + 138 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteersPhase 3
A Study to Evaluate the Immune Response and Safety of a Vaccine Against Influenza in Adults 18-64 Years of Age
GlaxoSmithKline
- Location
- Glendale, AZ + 11 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 3
Lot-to-lot Consistency Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From 2 Months of Age
Sanofi
- Location
- Fayetteville, AR + 13 other US sites
- Eligibility basics
- Ages 1 mo–2 mo
- RecruitingHealthy volunteersPhase 3
A Study of COVID-19 Vaccine(s) in Children and Adults
BioNTech SE
- Location
- Homestead, FL + 13 other US sites
- Eligibility basics
- Ages 5+
- RecruitingHealthy volunteersPhase 3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
Pfizer
- Location
- Birmingham, AL + 111 other US sites
- Eligibility basics
- Ages 0 mo–49
- RecruitingHealthy volunteersPhase 2
Safety and Efficacy of wSp Vaccine in Young Children
Serum Life Science Europe GmbH
- Location
- Pittsford, NY + 3 other US sites
- Eligibility basics
- Ages 5 mo–7 mo
- RecruitingHealthy volunteersPhase 3
A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age
GlaxoSmithKline
- Location
- Anniston, AL + 130 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteersPhase 3
A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants
Pfizer
- Location
- Estero, FL + 20 other US sites
- Eligibility basics
- Ages 1 mo–4 mo
- RecruitingHealthy volunteersPhase 3
Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and Adolescents
Pfizer
- Location
- Birmingham, AL + 49 other US sites
- Eligibility basics
- Ages 1–17
- RecruitingHealthy volunteersPhase 4
A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age
BioNTech SE
- Location
- Walnut Creek, CA + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 3
A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age
GlaxoSmithKline
- Location
- Birmingham, AL + 14 other US sites
- Eligibility basics
- Ages 1–6
- RecruitingHealthy volunteersPhase 3
A Study on the Safety of an Investigational Chickenpox Vaccine, When Given to Healthy Children, 12 to 15 Months of Age
GlaxoSmithKline
- Location
- Huntington Park, CA + 14 other US sites
- Eligibility basics
- Ages 1–1
Who these studies look for
Vaccine studies often exclude people who recently received a related vaccine or had the infection, and those with conditions or medicines that affect the immune system.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Could I receive a placebo?
Often yes. Many vaccine trials are randomized, so some participants receive a comparison vaccine or placebo. The consent document explains this.