Location · California
Clinical trials recruiting in California
1898 recruiting studies have at least one site in California; 701 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,898 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)
Bristol-Myers Squibb
- Location
- Culver City, CA + 20 other US sites
- Eligibility basics
- Ages 18–65
- Recruiting
AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions
Boston Scientific Corporation
- Location
- La Jolla, CA + 46 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Merck Sharp & Dohme LLC
- Location
- Irvine, CA + 34 other US sites
- Eligibility basics
- Ages 50–85
- RecruitingPhase 3
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Alnylam Pharmaceuticals
- Location
- La Jolla, CA + 40 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 3
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Zenas BioPharma (USA), LLC
- Location
- West Hollywood, CA + 18 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 3
Phase 3, Open-label, Single-dose Study of CSL222 in Adolescent Male Subjects (≥ 12 to < 18 Years of Age) With Severe or Moderately Severe Hemophilia B
CSL Behring
- Location
- Orange, CA + 5 other US sites
- Eligibility basics
- Ages 11–17 · Men only
- RecruitingPhase 3
A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia
Sanofi
- Location
- Duarte, CA + 26 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease
Sanofi
- Location
- Fontana, CA + 20 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Dose-masked Study of Intravitreal Remigromig (EYE103) in Participants With NVAMD or Macular Edema Following BRVO
EyeBiotech Ltd.
- Location
- Glendale, CA + 54 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Sanofi
- Location
- Beverly Hills, CA + 30 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 2
Transition to KPL-387 Monotherapy Dosing & Administration Study
Kiniksa Pharmaceuticals International, plc
- Location
- La Jolla, CA + 20 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 3
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
Medipost, Inc.
- Location
- El Cajon, CA + 33 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
Generate Biomedicines
- Location
- Bakersfield, CA + 21 other US sites
- Eligibility basics
- Ages 12–80
- RecruitingPhase 2
A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus
Alnylam Pharmaceuticals
- Location
- Chula Vista, CA
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy
Biomea Fusion Inc.
- Location
- Canoga Park, CA + 19 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome.
OHB Pediatrics Ltd.
- Location
- San Diego, CA + 4 other US sites
- Eligibility basics
- Ages 1–50
- RecruitingPhase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or…
AbbVie
- Location
- Tustin, CA + 11 other US sites
- Eligibility basics
- Ages 18–75
- Recruiting
Evaluation of Gixam's Efficacy Predicting the Presence of Advanced and Non-advanced Colorectal Neoplasia in a FIT Negative Population
Jubaan Ltd.
- Location
- Lancaster, CA + 7 other US sites
- Eligibility basics
- Ages 45–84
- RecruitingPhase 2
Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis
AbbVie
- Location
- Anaheim, CA + 60 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 2
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
AbbVie
- Location
- Concord, CA + 58 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
Study to Assess Linsitinib in Participants With Moderate to Severe Active Thyroid Eye Disease (TED)
Sling Therapeutics, Inc.
- Location
- Beverly Hills, CA + 16 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc.
- Location
- Redlands, CA + 10 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Evaluation of MiniMed Next Generation Extended Wear Sensors and Algorithm in Patients With Type 1 and Type 2 Diabetes
Medtronic MiniMed, Inc.
- Location
- Chula Vista, CA + 9 other US sites
- Eligibility basics
- Ages 2–80
- RecruitingPhase 3
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
Basilea Pharmaceutica
- Location
- Duarte, CA + 21 other US sites
- Eligibility basics
- Ages 18+