Phase 1 · California
Phase 1 clinical trials in California
262 studies have at least one recruiting site in California. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
262 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
Centrexion Therapeutics
- Location
- Napa, CA
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Tenaya Therapeutics
- Location
- La Jolla, CA + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata
Aldena Therapeutics
- Location
- Thousand Oaks, CA + 3 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1/Phase 2
A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis
Krystal Biotech, Inc.
- Location
- Pasadena, CA + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury
Lineage Cell Therapeutics, Inc.
- Location
- La Jolla, CA
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Study of ATX-01 in Participants With DM1
ARTHEx Biotech S.L.
- Location
- Los Angeles, CA + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingPhase 1/Phase 2
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
ModernaTX, Inc.
- Location
- Los Angeles, CA + 7 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Neurona Therapeutics
- Location
- Los Angeles, CA + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705
ModernaTX, Inc.
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 1+
- RecruitingPhase 1/Phase 2
A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa)
Beam Therapeutics Inc.
- Location
- Orange, CA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Treatment of Moderate to Severe Refractory Crohn's Disease
Tr1X, Inc.
- Location
- Sacramento, CA + 12 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease
GC Biopharma Corp
- Location
- Los Angeles, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Tolerability of RPE Stem Cell-derived RPE(RPESC-RPE) Transplantation in Patients With Dry Age-related Macular Degeneration (AMD)
Luxa Biotechnology, LLC
- Location
- Beverly Hills, CA + 2 other US sites
- Eligibility basics
- Ages 55+
- RecruitingPhase 1
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
PharmaIN
- Location
- Coronado, CA + 8 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
MSC EVs in Dystrophic Epidermolysis Bullosa
Aegle Therapeutics
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 6 mo+
- RecruitingPhase 1
Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®
Envivo Bio Inc
- Location
- Mountain View, CA
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
Ascentage Pharma Group Inc.
- Location
- Duarte, CA + 6 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
Tenaya Therapeutics
- Location
- San Francisco, CA + 6 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingEarly Phase 1
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
R3 Medical Research
- Location
- Beverly Hills, CA + 4 other US sites
- Eligibility basics
- Ages 30+
- RecruitingPhase 1/Phase 2
Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics
ViiV Healthcare
- Location
- Long Beach, CA + 5 other US sites
- Eligibility basics
- Ages 6–12
- RecruitingPhase 1
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain
R3 Stem Cell
- Location
- Beverly Hills, CA + 3 other US sites
- Eligibility basics
- Ages 20+
- RecruitingPhase 1/Phase 2
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Sardocor Corp.
- Location
- San Diego, CA + 4 other US sites
- Eligibility basics
- Ages 18–80
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.