Location · California
Clinical trials recruiting in California
1900 recruiting studies have at least one site in California; 700 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,900 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Novartis Pharmaceuticals
- Location
- Fullerton, CA + 42 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A
Hoffmann-La Roche
- Location
- Orange, CA + 5 other US sites
- Eligibility basics
- Ages 18+ · Men only
- RecruitingPhase 2/Phase 3
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)
Merck Sharp & Dohme LLC
- Location
- Los Angeles, CA + 22 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late-Onset Pompe Disease (PROGRESS-GT LOPD)
AskBio Inc
- Location
- Irvine, CA + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Sanofi
- Location
- Lancaster, CA + 33 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 3
A 52-Week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream in Adult Participants With Lichen Sclerosus
LEO Pharma
- Location
- Fremont, CA + 18 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
Hoffmann-La Roche
- Location
- Irvine, CA + 43 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
Hoffmann-La Roche
- Location
- Irvine, CA + 44 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
Boehringer Ingelheim
- Location
- Glendale, CA + 15 other US sites
- Eligibility basics
- Ages 12+
- RecruitingPhase 2/Phase 3
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
Sanofi
- Location
- San Francisco, CA + 13 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 2
A Phase IIb Dose-ranging Study to Assess the Efficacy and Safety of GIA632 in Participants With Non-segmental Vitiligo
Novartis Pharmaceuticals
- Location
- Fountain Valley, CA + 23 other US sites
- Eligibility basics
- Ages 18–99
- RecruitingPhase 2
A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Novartis Pharmaceuticals
- Location
- Huntington Beach, CA + 14 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)
Insmed Incorporated
- Location
- Los Angeles, CA + 10 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
Axsome Therapeutics, Inc.
- Location
- Bellflower, CA + 35 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1
Dyne Therapeutics
- Location
- La Jolla, CA + 13 other US sites
- Eligibility basics
- Ages 16+
- RecruitingPhase 1/Phase 2
First-in-human Study of UX016 in GNEM
Ultragenyx Pharmaceutical Inc
- Location
- Orange, CA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingPhase 2
A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma
AstraZeneca
- Location
- Bakersfield, CA + 11 other US sites
- Eligibility basics
- Ages 4–11
- RecruitingPhase 3
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
Janssen Research & Development, LLC
- Location
- Anaheim, CA + 23 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy
Hoffmann-La Roche
- Location
- Glendale, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
Pfizer
- Location
- Canoga Park, CA + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea.
Incannex Healthcare Ltd
- Location
- Chula Vista, CA + 11 other US sites
- Eligibility basics
- Ages 18–65
- Recruiting
Cryoablation for Monomorphic Ventricular Tachycardia (VTS)
Adagio Medical
- Location
- Long Beach, CA + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
An Extension Study to Assess Safety and Efficacy of Remibrutinib in Participants With Moderate to Severe HS
Novartis Pharmaceuticals
- Location
- Fremont, CA + 20 other US sites
- Eligibility basics
- Ages 18–100
- RecruitingPhase 3
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
AstraZeneca
- Location
- Lynwood, CA + 43 other US sites
- Eligibility basics
- Ages 18+