Location · California
Clinical trials recruiting in California
1900 recruiting studies have at least one site in California; 700 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,900 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 1/Phase 2
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
Kamau Therapeutics
- Location
- Los Angeles, CA + 5 other US sites
- Eligibility basics
- Ages 12–50
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Alexion Pharmaceuticals, Inc.
- Location
- San Francisco, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study of CDX-622 in Participants With Mild to Moderate Asthma
Celldex Therapeutics
- Location
- San Francisco, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Study of 2 Medicines (Aztreonam and Avibactam) Compared to Best Available Therapy for Serious Gram-negative Infections
Pfizer
- Location
- San Diego, CA + 2 other US sites
- Eligibility basics
- Ages 10 mo–17
- RecruitingPhase 3
Study to Evaluate Long-Term Safety of Intravitreal OTX-TKI (Axitinib Implant) in Participants With Neovascular Age-Related Macular Degeneration Who Successfully Completed 2-Year OTX-TKI-2023-AMD-301 or…
Ocular Therapeutix, Inc.
- Location
- Bakersfield, CA + 7 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Sonoma Biotherapeutics, Inc.
- Location
- San Francisco, CA + 8 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery
Corza Medical GmbH
- Location
- Torrance, CA + 8 other US sites
- Eligibility basics
- Ages 1 mo+
- RecruitingPhase 3
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
Bristol-Myers Squibb
- Location
- Chino, CA + 2 other US sites
- Eligibility basics
- Ages 55–90
- RecruitingPhase 1
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
GlaxoSmithKline
- Location
- Fair Oaks, CA + 11 other US sites
- Eligibility basics
- Ages 65–85
- Recruiting
Optimizing Extended-Duration (XD-) TOMAC Therapy for Restless Legs Syndrome (RLS)
Noctrix Health, Inc.
- Location
- Pleasanton, CA
- Eligibility basics
- Ages 21+
- Recruiting
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Endotronix, Inc.
- Location
- Los Angeles, CA + 43 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
Pharming Technologies B.V.
- Location
- Orange, CA + 10 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair
Auxilium Biotechnologies
- Location
- San Diego, CA + 7 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 2
Atacicept in Multiple Glomerular Diseases
Vera Therapeutics, Inc.
- Location
- Brisbane, CA
- Eligibility basics
- Ages 2+
- RecruitingPhase 3
A Study of SNP-ACTH (1-39) Gel in Patients With Primary Membranous Nephropathy
Cerium Pharmaceuticals, Inc.
- Location
- Los Angeles, CA + 18 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Integrity Implant System Post Market Clinical Follow-Up Study
Anika Therapeutics, Inc.
- Location
- Pomona, CA + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in…
Apellis Pharmaceuticals, Inc.
- Location
- Bakersfield, CA + 77 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 3
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Ansun Biopharma, Inc.
- Location
- Duarte, CA + 18 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 2
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Novartis Pharmaceuticals
- Location
- Beverly Hills, CA + 29 other US sites
- Eligibility basics
- Ages 50–80
- RecruitingPhase 2
Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)
Shionogi
- Location
- Irvine, CA + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
Bristol-Myers Squibb
- Location
- Bellflower, CA + 19 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
Neurocrine Biosciences
- Location
- Chino, CA + 17 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
DalCor Pharmaceuticals
- Location
- Huntington Beach, CA + 112 other US sites
- Eligibility basics
- Ages 45+
- RecruitingPhase 3
Study to Evaluate the Efficacy and Safety of Oral Rilzabrutinib in Adults With Immune Thrombocytopenia (ITP) Who Failed First-line Treatment
Sanofi
- Location
- Clovis, CA + 11 other US sites
- Eligibility basics
- Ages 18+