Mental health · California
Mental health studies in California
146 studies have at least one recruiting site in California. Mental health research includes studies of depression, anxiety, PTSD, bipolar disorder, schizophrenia and ADHD, testing medicines, devices and talk therapies.
146 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 2
Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
Autobahn Therapeutics, Inc.
- Location
- Anaheim, CA + 31 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
Randomized Withdrawal Study in Patients With Schizophrenia
Vanda Pharmaceuticals
- Location
- Costa Mesa, CA + 21 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Study of ALTO-101 in Patients With Schizophrenia
Alto Neuroscience
- Location
- Garden Grove, CA + 12 other US sites
- Eligibility basics
- Ages 21–55
- RecruitingPhase 3
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Neurocrine Biosciences
- Location
- Orange, CA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Study of ALTO-300 in MDD
Alto Neuroscience
- Location
- Bellflower, CA + 36 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 4
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
Axsome Therapeutics, Inc.
- Location
- Bellflower, CA + 36 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2/Phase 3
An Adaptive Phase II/III, Two-Part, Double-Blind, Randomized, Placebo-controlled, Dose-Finding, Multi-center Study of the Safety and Efficacy of NaBen®, as an Add-on Therapy With Clozapine, for Residual Symptoms of…
SyneuRx International (Taiwan) Corp
- Location
- Pasadena, CA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteers
MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
California State University, Northridge
- Location
- Northridge, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Very Brief Exposure: Development of a Novel Exposure Modality for Social Anxiety Disorder in Transition-Age Youth
Children's Hospital Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 16–22
- RecruitingHealthy volunteers
K08 VR Fear Conditioning
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteers
Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1
Washington University School of Medicine
- Location
- Irvine, CA + 4 other US sites
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteers
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Duke University
- Location
- Los Angeles, CA + 1 other US site
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteers
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Duke University
- Location
- Palo Alto, CA + 3 other US sites
- Eligibility basics
- Ages 0 mo–20
- RecruitingHealthy volunteersPhase 4
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
VA Office of Research and Development
- Location
- Loma Linda, CA + 8 other US sites
- Eligibility basics
- Ages 40+
- RecruitingHealthy volunteers
Aromatherapy and Its Impact on Preoperative Anxiety, Postoperative Pain, and Patient Experience
Kaiser Permanente
- Location
- Stockton, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Inter-Brain Synchrony in Schizophrenia
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 2
Mindfulness-Assisted Psychedelic Therapy
University of Southern California
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 25+
- RecruitingHealthy volunteers
The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans
Children's Hospital Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteers
Tactile Pre-Visit Imagery
University of Southern California
- Location
- Los Angeles, CA + 1 other US site
- Eligibility basics
- Ages 4–10
- RecruitingHealthy volunteers
Improving Behavioral Health for Caregivers and Children After Pediatric Injury
Medical University of South Carolina
- Location
- Los Angeles, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Teen Helpline Motivational Interviewing Study
San Diego State University
- Location
- San Diego, CA
- Eligibility basics
- Ages 13+
- RecruitingHealthy volunteers
Sleep TMS for Depression
Stanford University
- Location
- Stanford, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 4
Computational Assessment of GABA Receptor Modulation in PTSD
VA Office of Research and Development
- Location
- San Diego, CA
- Eligibility basics
- Ages 18–65
Who these studies look for
Studies usually require a confirmed diagnosis and stable circumstances, and they monitor safety closely. If you are in crisis, contact a crisis line or emergency services rather than a study.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Will joining affect my current treatment?
Some studies require changes to medicines, which the study team manages; others add to your usual care. Talk to your own clinician before making any change.