Phase 1 · California
Phase 1 clinical trials in California
262 studies have at least one recruiting site in California. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
262 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy
Michael Randall
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Precision Dosing of Metformin in Youth With T2D
University of California, San Francisco
- Location
- Oakland, CA + 1 other US site
- Eligibility basics
- Ages 10–21
- RecruitingHealthy volunteersPhase 1
THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersPhase 1
Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
University of California, Berkeley
- Location
- Berkeley, CA
- Eligibility basics
- Ages 60–85
- RecruitingHealthy volunteersEarly Phase 1
Vocal Emotion Communication With Cochlear Implants
Father Flanagan's Boys' Home
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 6–80
- RecruitingHealthy volunteersPhase 1
1726-nm Laser for Acne Inversa (Hidradenitis Suppurativa)
Wynn Medical Center
- Location
- Rosemead, CA
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Azithromycin Before Induction
Arrowhead Regional Medical Center
- Location
- Colton, CA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersPhase 1
PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
David Wilson
- Location
- San Francisco, CA
- Eligibility basics
- Ages 40–75
- RecruitingHealthy volunteersPhase 1
Imaging Synapses With [11C] UCB-J in the Human Brain
Davidzon, Guido, M.D.
- Location
- Palo Alto, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
CogT pSOPT Intervention Study
Stanford University
- Location
- Palo Alto, CA
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Sacramento Pediatric Gastroenterology
- Location
- Sacramento, CA
- Eligibility basics
- Ages 0 mo–40
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Encoded Therapeutics
- Location
- San Francisco, CA + 9 other US sites
- Eligibility basics
- Ages 6 mo–17
- RecruitingPhase 1
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Verve Therapeutics, Inc.
- Location
- Garden Grove, CA + 4 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- La Jolla, CA + 7 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Los Angeles, CA + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
Sumitomo Pharma America, Inc.
- Location
- La Jolla, CA + 2 other US sites
- Eligibility basics
- Ages 40–72
- RecruitingPhase 1
Safety and Preliminary Efficacy of ULSC in Facioscapulohumeral Muscular Dystrophy (FSHD)
Restem, LLC.
- Location
- Palo Alto, CA
- Eligibility basics
- Ages 15+
- RecruitingPhase 1/Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Sanofi
- Location
- Beverly Hills, CA + 30 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or…
AbbVie
- Location
- Tustin, CA + 11 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis
Cabaletta Bio
- Location
- Orange, CA + 16 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
- Location
- La Jolla, CA + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual Treatment
Kite, A Gilead Company
- Location
- Newport Beach, CA + 4 other US sites
- Eligibility basics
- Ages 18–75
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.