Location · California
Clinical trials recruiting in California
1898 recruiting studies have at least one site in California; 701 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,898 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 3
A Trial of Inebilizumab in Participants With Autoimmune Hepatitis
Amgen
- Location
- Rialto, CA + 5 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 3
Pridopidine Phase 3 Study in Huntington's Disease
Prilenia
- Location
- La Jolla, CA + 8 other US sites
- Eligibility basics
- Ages 23–65
- RecruitingPhase 1
An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis
Hoffmann-La Roche
- Location
- Chula Vista, CA + 2 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 2
ADAPT Forward 2 - ISA2 - a Study to Evaluate the Safety, Tolerability and Efficacy of Empasiprubart IV Monotherapy in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis
argenx
- Location
- Carlsbad, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine
Kallyope Inc.
- Location
- Colton, CA + 111 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Resmetirom in Patients With MASH and HFpEF
Madrigal Pharmaceuticals, Inc.
- Location
- Oxnard, CA + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Semaglutide Medication
Novo Nordisk A/S
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication
Novo Nordisk A/S
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18+
- Recruiting
Brain-Computer Interface Communication Device for People With ALS
Cognixion
- Location
- Santa Barbara, CA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With…
Cabaletta Bio
- Location
- Redwood City, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
Sanofi
- Location
- La Jolla, CA + 17 other US sites
- Eligibility basics
- Ages 18–90
- RecruitingPhase 2/Phase 3
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
Cabaletta Bio
- Location
- Orange, CA + 29 other US sites
- Eligibility basics
- Ages 6–75
- RecruitingPhase 3
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Akero Therapeutics, Inc
- Location
- Coronado, CA + 131 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 3
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
Novartis Pharmaceuticals
- Location
- Orange, CA + 16 other US sites
- Eligibility basics
- Ages 12–100
- RecruitingPhase 2
A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)
Pfizer
- Location
- Orange, CA + 10 other US sites
- Eligibility basics
- Up to age 10 mo
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
UCB Biopharma SRL
- Location
- Beverly Hills, CA + 61 other US sites
- Eligibility basics
- Ages 16+
- RecruitingPhase 3
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Vertex Pharmaceuticals Incorporated
- Location
- Fresno, CA + 57 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 2
A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.
Novartis Pharmaceuticals
- Location
- Sylmar, CA + 3 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 3
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
Pfizer
- Location
- Bakersfield, CA + 76 other US sites
- Eligibility basics
- Ages 12+
- RecruitingPhase 1
A Study to Learn About How Changing Therapy From Emicizumab to Marstacimab Affects People With the Severe Hemophilia A.
Pfizer
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 12–74 · Men only
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
BlueRock Therapeutics
- Location
- Los Angeles, CA + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Study to Investigate Efficacy and Safety of Brivekimig in Participants With Crohn's Disease
Sanofi
- Location
- Escondido, CA + 18 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Sanofi
- Location
- Clovis, CA + 20 other US sites
- Eligibility basics
- Ages 10–65
- Recruiting
Renal Pelvic Denervation Pilot Trial
Verve Medical, Inc
- Location
- Los Angeles, CA + 7 other US sites
- Eligibility basics
- Ages 21–80