Location · California
Clinical trials recruiting in California
1900 recruiting studies have at least one site in California; 700 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,900 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 1
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Rocket Pharmaceuticals Inc.
- Location
- La Jolla, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Centessa Pharmaceuticals (UK) Limited
- Location
- Santa Ana, CA + 18 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety of a Single Intravitreal Injection of RTx-021 in Patients With Stargardt Disease
Ray Therapeutics, Inc.
- Location
- Bakersfield, CA + 2 other US sites
- Eligibility basics
- Ages 16+
- RecruitingPhase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Amylyx Pharmaceuticals Inc.
- Location
- La Jolla, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
Paradromics
- Location
- Sacramento, CA + 2 other US sites
- Eligibility basics
- Ages 22–75
- Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Cardiac Dimensions, Inc.
- Location
- Los Angeles, CA + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia
ReAlta Life Sciences, Inc.
- Location
- Orange, CA + 13 other US sites
- Eligibility basics
- Any age listed
- Recruiting
Accuracy and Precision of the Continuous Glucose Monitoring System 'CareSens Air 3' in Adult Patients With T1DM
i-SENS, Inc.
- Location
- Walnut Creek, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Corneal Scars
Claris Biotherapeutics, Inc.
- Location
- Loma Linda, CA + 6 other US sites
- Eligibility basics
- Ages 18–80
- Recruiting
Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC
Surgenex
- Location
- Vista, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus
Op-T LLC
- Location
- Walnut Creek, CA + 4 other US sites
- Eligibility basics
- Ages 18–50
- RecruitingPhase 3
A Study to Assess How Effective and Safe NVD003 is for Treating Patients With Congenital Pseudarthrosis of the Tibia.
Novadip Biosciences
- Location
- Loma Linda, CA + 3 other US sites
- Eligibility basics
- Up to age 17
- RecruitingPhase 2
A Study of Vosoritide Versus Placebo in Children With Hypochondroplasia Aged 0 to < 36 Months
BioMarin Pharmaceutical
- Location
- Oakland, CA + 6 other US sites
- Eligibility basics
- Ages 0 mo–3
- RecruitingPhase 2
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
RECORDATI GROUP
- Location
- San Francisco, CA + 3 other US sites
- Eligibility basics
- Ages 2–17
- RecruitingPhase 3
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Intellia Therapeutics
- Location
- Los Angeles, CA + 36 other US sites
- Eligibility basics
- Ages 18–90
- RecruitingPhase 3
To Investigate the Efficacy of Treatment With Oral NA-921 (Bionetide) Versus Placebo in Females With Rett Syndrome
Biomed Industries, Inc.
- Location
- La Jolla, CA + 13 other US sites
- Eligibility basics
- Ages 5–20 · Women only
- RecruitingPhase 3
Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera
Italfarmaco
- Location
- Redlands, CA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
Supernus Pharmaceuticals, Inc.
- Location
- Garden Grove, CA
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
ModernaTX, Inc.
- Location
- Palo Alto, CA + 5 other US sites
- Eligibility basics
- Ages 1+
- RecruitingPhase 1
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
Centrexion Therapeutics
- Location
- Napa, CA
- Eligibility basics
- Ages 18–75
- Recruiting
Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion
Kuros Biosurgery AG
- Location
- Irvine, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Tenaya Therapeutics
- Location
- La Jolla, CA + 4 other US sites
- Eligibility basics
- Ages 18–75
- Recruiting
XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)
XVIVO Perfusion
- Location
- La Jolla, CA + 13 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis
Baxis Pharmaceuticals, Inc.
- Location
- La Jolla, CA + 20 other US sites
- Eligibility basics
- Any age listed