Weight loss · Missouri
Weight loss and obesity studies in Missouri
43 studies have at least one recruiting site in Missouri. Weight-management research includes trials of new medicines, devices, diets and lifestyle programs for people with overweight or obesity, and studies of weight-related conditions such as fatty liver disease.
43 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Amgen
- Location
- Kansas City, MO + 117 other US sites
- Eligibility basics
- Ages 18–99
- RecruitingPhase 3
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
Novo Nordisk A/S
- Location
- City of Saint Peters, MO + 14 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and…
Novo Nordisk A/S
- Location
- St Louis, MO + 55 other US sites
- Eligibility basics
- Ages 45+
- RecruitingPhase 3
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Novo Nordisk A/S
- Location
- Springfield, MO + 17 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Hazelwood, MO + 12 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
- Location
- Kansas City, MO + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study
St. Louis University
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–35
- RecruitingHealthy volunteers
Role of KATP Channel Loss in Type 2 Diabetes
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Advancing Biopsychosocial Care Training Initiative
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 5+
- RecruitingHealthy volunteers
Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)
Bettina Mittendorfer
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteers
Small Extracellular Vesicles and Insulin Action
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 25–55
- RecruitingHealthy volunteersPhase 2
Effect of Ketone Esters on Liver Fat Content and Metabolic Function
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteers
Alzheimer"s Imaging Biomarkers in Obesity
Cyrus A Raji
- Location
- St Louis, MO
- Eligibility basics
- Ages 40–60
- RecruitingHealthy volunteers
Growth Hormone Resistance of Beta-cells A
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteers
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteers
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Bettina Mittendorfer
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteers
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Washington University School of Medicine
- Location
- St Louis, MO + 1 other US site
- Eligibility basics
- Ages 12–17
- RecruitingHealthy volunteers
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 2
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
University of Missouri, Kansas City
- Location
- Kansas City, MO
- Eligibility basics
- Ages 18+
Who these studies look for
Most of these studies set a BMI range and may exclude people taking certain weight-loss medicines or who have had bariatric surgery. Some require a weight-related condition such as type 2 diabetes or high blood pressure.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Can I join a weight loss study if I already take a GLP-1 medicine?
It depends on the study. Many exclude people currently or recently on weight-loss medicines; others are designed specifically for them. The listing’s eligibility criteria and the study team are the only reliable answer.