Location · California
Clinical trials recruiting in California
1900 recruiting studies have at least one site in California; 700 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,900 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
More recruiting studies (pay not posted)
- Recruiting
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
Axon Therapies, Inc.
- Location
- La Jolla, CA + 15 other US sites
- Eligibility basics
- Ages 40+
- Recruiting
TVMR With the INNOVALVE System Trial - Early Feasibility Study
Edwards Lifesciences
- Location
- Los Angeles, CA + 18 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2/Phase 3
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
CSL Behring
- Location
- Bakersfield, CA + 147 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)
VDyne, Inc.
- Location
- Los Angeles, CA + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
Kyowa Kirin Co., Ltd.
- Location
- San Francisco, CA + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)
Merck Sharp & Dohme LLC
- Location
- Garden Grove, CA + 12 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
Arrowhead Pharmaceuticals
- Location
- Los Angeles, CA + 16 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2/Phase 3
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
Corxel Pharmaceuticals
- Location
- Long Beach, CA + 19 other US sites
- Eligibility basics
- Ages 18–90
- RecruitingPhase 2
Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease
Hillhurst Biopharmaceuticals, Inc.
- Location
- Fountain Valley, CA + 4 other US sites
- Eligibility basics
- Ages 40–80
- RecruitingPhase 3
Study of Oral Deucrictibant XR Tablet for Prophylaxis and Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adults With Acquired Angioedema Due to C1 Inhibitor Deficiency
Pharvaris Netherlands B.V.
- Location
- San Diego, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2/Phase 3
Evaluation of the Efficacy and Safety of THRV-1268 in Participants With Long QT Syndrome Type 2 (LQTS2) and Type 3 (LQTS3)
Thryv Therapeutics, Inc.
- Location
- San Francisco, CA + 6 other US sites
- Eligibility basics
- Ages 15+
- RecruitingPhase 2/Phase 3
A Study of Buntanetap in Participants With PD
Annovis Bio Inc.
- Location
- Fountain Valley, CA + 26 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingPhase 1/Phase 2
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Tr1X, Inc.
- Location
- La Jolla, CA + 7 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Phase I/II Trial of JR-446 in Mucopolysaccharidosis Type IIIB (MPS IIIB)
JCR Pharmaceuticals Co., Ltd.
- Location
- Oakland, CA
- Eligibility basics
- Up to age 5
- RecruitingPhase 2
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
AstraZeneca
- Location
- Newport Beach, CA + 3 other US sites
- Eligibility basics
- Ages 40+
- Recruiting
HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs
ReGelTec, Inc.
- Location
- Santa Monica, CA + 13 other US sites
- Eligibility basics
- Ages 22–85
- RecruitingPhase 3
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Novo Nordisk A/S
- Location
- Los Angeles, CA + 8 other US sites
- Eligibility basics
- Ages 2+
- RecruitingPhase 3
A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
Takeda
- Location
- Los Angeles, CA + 16 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps
Optinose US Inc.
- Location
- Orange, CA + 18 other US sites
- Eligibility basics
- Ages 12–17
- RecruitingPhase 1
A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)
UCB Biopharma SRL
- Location
- Santa Monica, CA + 5 other US sites
- Eligibility basics
- Ages 18+ · Women only
- RecruitingPhase 4
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Neurocrine Biosciences
- Location
- Chino, CA + 18 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
AstraZeneca
- Location
- Fullerton, CA + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2/Phase 3
Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
Vertex Pharmaceuticals Incorporated
- Location
- Los Angeles, CA + 26 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
AbbVie
- Location
- Irvine, CA + 10 other US sites
- Eligibility basics
- Ages 50–90