Phase 1 · Pennsylvania
Phase 1 clinical trials in Pennsylvania
102 studies have at least one recruiting site in Pennsylvania. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
102 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersEarly Phase 1
18F-FTHA IMAGING OF THE INTESTINAL AND CENTRAL LYMPHATIC SYSTEM
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Endometriosis and Microvascular Dysfunction: Role of Inflammation
Penn State University
- Location
- University Park, PA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersPhase 1
Pharmacogenetics of Response to GLP1R Agonists
University of Maryland, Baltimore
- Location
- Lancaster, PA
- Eligibility basics
- Ages 18–89
- RecruitingHealthy volunteersEarly Phase 1
Autonomic Control of the Circulation and VDR
Milton S. Hershey Medical Center
- Location
- Hershey, PA
- Eligibility basics
- Ages 21–35
- RecruitingHealthy volunteersEarly Phase 1
Imaging CRF X NOP Interactions in CUD
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Imaging CRF X NOP Interactions in Alcohol Use Disorder
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Ketamine and Propofol NeuroImaging
Keith M Vogt
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
University of Pennsylvania
- Location
- Philadelphia, PA + 2 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingHealthy volunteersEarly Phase 1
Remimazolam NeuroImaging
Keith M Vogt
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersPhase 1
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Children's Hospital of Philadelphia
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Localizing Epileptic Networks Using MRI and iEEG
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Identification of Critical Thermal Environments for Aged Adults
Penn State University
- Location
- University Park, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
PET Image in PAH Patients
Stephen Y. Chan
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 40–80
- RecruitingHealthy volunteersPhase 1
Applying pGz in Mitochondrial Disease
Children's Hospital of Philadelphia
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 10–60
- RecruitingHealthy volunteersPhase 1/Phase 2
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Philadelphia, PA + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Sanofi
- Location
- Bethlehem, PA + 30 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 1/Phase 2
An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease
Calico Life Sciences LLC
- Location
- Philadelphia, PA + 2 other US sites
- Eligibility basics
- Ages 6 mo+
- RecruitingPhase 1/Phase 2
DFT383 in Pediatric Participants With Nephropathic Cystinosis
Novartis Pharmaceuticals
- Location
- Philadelphia, PA + 5 other US sites
- Eligibility basics
- Ages 2–5
- RecruitingPhase 1/Phase 2
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With…
Cabaletta Bio
- Location
- Philadelphia, PA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
BlueRock Therapeutics
- Location
- Philadelphia, PA + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Safety and Efficacy of Soquelitinib in Adults With Hidradenitis Suppurativa
Corvus Pharmaceuticals, Inc.
- Location
- Camp Hill, PA + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).
Novartis Pharmaceuticals
- Location
- Pittsburgh, PA + 10 other US sites
- Eligibility basics
- Ages 2–17
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.