Study type
Weight loss and obesity studies recruiting now
Weight-management research includes trials of new medicines, devices, diets and lifestyle programs for people with overweight or obesity, and studies of weight-related conditions such as fatty liver disease.
365 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingHealthy volunteersOvernight stay mentioned
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
Bettina Mittendorfer
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersOvernight stay mentioned
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Bettina Mittendorfer
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersEarly Phase 1
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Pharmacogenetics of Response to GLP1R Agonists
University of Maryland, Baltimore
- Location
- Lancaster, PA
- Eligibility basics
- Ages 18–89
- RecruitingHealthy volunteersOvernight stay mentioned
The Osteoarthritis Prevention Study
Wake Forest University
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 50+ · Women only
- RecruitingHealthy volunteersPhase 1
Hormones, Outcomes, and Pain Pathways in Exercise Study
University of Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18–60 · Women only
- RecruitingHealthy volunteersOvernight stay mentioned
Experimental Approach to Test Predictions of Body Weight Regulation Models
Pennington Biomedical Research Center
- Location
- Baton Rouge, LA
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersOvernight stay mentioned
Circadian Rhythms in Human Adipose
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis Insulin Regulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Insulin Regulation of Lipolysis and Lipolysis Proteins
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Falls Church, VA
- Eligibility basics
- Ages 0 mo–50
- RecruitingHealthy volunteersPhase 1/Phase 2
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
University of North Carolina, Chapel Hill
- Location
- Chapel Hill, NC + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 3
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Birmingham, AL + 55 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingHealthy volunteersPhase 3
A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
Vanda Pharmaceuticals
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Hunger Perception and Weight-Related Outcomes Following Use of a Leptin-Supporting Dietary Supplement
Efforia, Inc
- Location
- New York, NY
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
Amgen
- Location
- Pelham, AL + 51 other US sites
- Eligibility basics
- Ages 18–99
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Two Formulations of ASC36 Injection in Participants With Obesity or Overweight
Ascletis Pharma (China) Co., Limited
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC36 Tablets for Oral Use in Adult Participants With Obesity or Overweight
Ascletis Pharma (China) Co., Limited
- Location
- South Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
AbbVie
- Location
- Pelham, AL + 58 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes
Novo Nordisk A/S
- Location
- Boynton Beach, FL + 13 other US sites
- Eligibility basics
- Ages 10–18
- RecruitingPhase 1
Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events
Novo Nordisk A/S
- Location
- Walnut Creek, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Semaglutide Medication
Novo Nordisk A/S
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication
Novo Nordisk A/S
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18+
Who these studies look for
Most of these studies set a BMI range and may exclude people taking certain weight-loss medicines or who have had bariatric surgery. Some require a weight-related condition such as type 2 diabetes or high blood pressure.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Can I join a weight loss study if I already take a GLP-1 medicine?
It depends on the study. Many exclude people currently or recently on weight-loss medicines; others are designed specifically for them. The listing’s eligibility criteria and the study team are the only reliable answer.