Location · California
Clinical trials recruiting in California
1900 recruiting studies have at least one site in California; 700 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in California.
1,900 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 3
A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus
AstraZeneca
- Location
- La Palma, CA + 14 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
Janssen Research & Development, LLC
- Location
- Beverly Hills, CA + 37 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
Janssen Research & Development, LLC
- Location
- Anaheim, CA + 35 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation
Biosense Webster, Inc.
- Location
- Santa Monica, CA + 10 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 2
A Study of JADE101 in Participants With Immunoglobulin A Nephropathy
Jade Biosciences, Inc.
- Location
- Chula Vista, CA + 5 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 2
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals, Inc.
- Location
- Buena Park, CA + 25 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
- Location
- Redlands, CA + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
AstraZeneca
- Location
- Lincoln, CA + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Pfizer
- Location
- Anaheim, CA + 69 other US sites
- Eligibility basics
- Ages 6–17
- RecruitingPhase 3
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
Pfizer
- Location
- Anaheim, CA + 54 other US sites
- Eligibility basics
- Ages 6–17
- Recruiting
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
Edwards Lifesciences
- Location
- Los Angeles, CA + 30 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 1/Phase 2
Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease
UniQure Biopharma B.V.
- Location
- Los Angeles, CA + 9 other US sites
- Eligibility basics
- Ages 18–65 · Men only
- RecruitingPhase 3
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic…
AstraZeneca
- Location
- Irvine, CA + 31 other US sites
- Eligibility basics
- Ages 18–75
- Recruiting
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
SoniVie Inc.
- Location
- Los Angeles, CA + 33 other US sites
- Eligibility basics
- Ages 22–75
- RecruitingPhase 3
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Vanda Pharmaceuticals
- Location
- Garden Grove, CA + 24 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
Azafaros B.V.
- Location
- Oakland, CA + 4 other US sites
- Eligibility basics
- Ages 4+
- RecruitingPhase 2
A Study to Examine Anktiva for the Treatment of COVID-19.
ImmunityBio, Inc.
- Location
- El Segundo, CA
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
Eli Lilly and Company
- Location
- Beverly Hills, CA + 120 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Tolerability of Subretinally Injected OPGx-BEST1 in Patients With Best Vitelliform Macular Dystrophy (BVMD) or Autosomal-Recessive Bestrophinopathy (ARB)
Opus Genetics, Inc
- Location
- Los Angeles, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.
Granata Bio Corporation
- Location
- Encino, CA + 14 other US sites
- Eligibility basics
- Ages 18–42 · Women only
- RecruitingPhase 2
ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod
argenx
- Location
- Carlsbad, CA + 13 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
ENV-294 for Moderate-to-Severe Asthma: A 12-Week Study in Adults
Enveda Therapeutics
- Location
- Los Angeles, CA + 19 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 3
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)
Adverum Biotechnologies, Inc.
- Location
- Bakersfield, CA + 78 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 2
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
Reunion Neuroscience Inc
- Location
- Garden Grove, CA + 26 other US sites
- Eligibility basics
- Ages 18–74