Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
A Study of Andecaliximab in People With Spinal Cord Injury at Risk for Bone Growth Outside of the Normal Skeleton.
Ashibio Inc
- Location
- Denver, CO
- Eligibility basics
- Ages 18–89
- RecruitingPhase 1
Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®
Envivo Bio Inc
- Location
- Mountain View, CA
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1
BAFF CAR-T Cells (LMY-920) for Systemic Lupus Erythematosus
Luminary Therapeutics
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Autologous Adipose Cells Therapy
CERM INC.
- Location
- Lewes, DE + 1 other US site
- Eligibility basics
- Ages 21–80
- RecruitingPhase 1/Phase 2
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)
Splice Bio
- Location
- Aurora, CO + 4 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingPhase 1
Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure
Medley Therapeutics
- Location
- Houston, TX
- Eligibility basics
- Ages 18–79
- RecruitingPhase 1
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
Ascentage Pharma Group Inc.
- Location
- Duarte, CA + 6 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Secretome Therapeutics
- Location
- Dallas, TX
- Eligibility basics
- Ages 18+
- RecruitingEarly Phase 1
A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction
Arcato Laboratories, Inc.
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1
Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy
Sardocor Corp.
- Location
- Kansas City, KS + 2 other US sites
- Eligibility basics
- Ages 18+ · Men only
- RecruitingPhase 1
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
Caregen Co. Ltd.
- Location
- Manchester, CT + 6 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
Tenaya Therapeutics
- Location
- San Francisco, CA + 6 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
Study of SFA002 in Patients with Mild to Moderate Psoriasis Plaques
SFA Therapeutics
- Location
- Pompano Beach, FL + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects
Helios Cardio Inc.
- Location
- Louisville, KY
- Eligibility basics
- Ages 20–85
- RecruitingPhase 1/Phase 2
A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
Spirovant Sciences, Inc.
- Location
- Kansas City, KS + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingEarly Phase 1
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
R3 Medical Research
- Location
- Scottsdale, AZ + 4 other US sites
- Eligibility basics
- Ages 30+
- RecruitingPhase 1/Phase 2
Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics
ViiV Healthcare
- Location
- Long Beach, CA + 5 other US sites
- Eligibility basics
- Ages 6–12
- RecruitingPhase 1
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain
R3 Stem Cell
- Location
- Scottsdale, AZ + 3 other US sites
- Eligibility basics
- Ages 20+
- RecruitingPhase 1/Phase 2
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Sardocor Corp.
- Location
- San Diego, CA + 4 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
Sardocor Corp.
- Location
- Durham, NC
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
Study of TL-895 Combined With Ruxolitinib in JAKi Treatment-Naïve MF Subjects and Subjects With MF Who Have a Suboptimal Response to Ruxolitinib
Telios Pharma, Inc.
- Location
- Birmingham, AL + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
ASC618 Gene Therapy in Hemophilia A Patients
ASC Therapeutics
- Location
- Little Rock, AR
- Eligibility basics
- Ages 18+ · Men only
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.