Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
Lateral Plantar Artery Embolization For Plantar Fasciitis
Joint & Vascular Institute
- Location
- Libertyville, IL
- Eligibility basics
- Ages 25–80
- RecruitingPhase 1/Phase 2
Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms
U: The Mind Company
- Location
- Cleveland, OH
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1/Phase 2
BS01 in Patients With Retinitis Pigmentosa
Bionic Sight LLC
- Location
- Teaneck, NJ
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study to Evaluate the Safety and Efficacy of Intravitreal Administration of BS01 in Patients With Geographic Atrophy Secondary to Dry AMD
Bionic Sight LLC
- Location
- Edison, NJ
- Eligibility basics
- Ages 50–85
- RecruitingPhase 1/Phase 2
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
ModernaTX, Inc.
- Location
- Los Angeles, CA + 7 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Neurona Therapeutics
- Location
- Little Rock, AR + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety and Clinical Activity of Intramuscular Doses of BB-301 Administered to Subjects With Oculopharyngeal Muscular Dystrophy With Dysphagia
Benitec Biopharma, Inc.
- Location
- New York, NY
- Eligibility basics
- Up to age 65
- RecruitingPhase 1
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
Pacira Pharmaceuticals, Inc
- Location
- Indianapolis, IN + 4 other US sites
- Eligibility basics
- Ages 0 mo–6
- RecruitingPhase 1/Phase 2
An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705
ModernaTX, Inc.
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 1+
- RecruitingPhase 1
Safety and Pharmacokinetics of LPX-TI641 in Atopic Dermatitis and Psoriasis
LAPIX Therapeutics Inc.
- Location
- Fargo, ND + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa)
Beam Therapeutics Inc.
- Location
- Orange, CA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Orbit Study: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered ION356 in Participants With Pelizaeus Merzbacher Disease (PMD)
Ionis Pharmaceuticals, Inc.
- Location
- Atlanta, GA + 2 other US sites
- Eligibility basics
- Ages 2–17 · Men only
- RecruitingPhase 1/Phase 2
Treatment of Moderate to Severe Refractory Crohn's Disease
Tr1X, Inc.
- Location
- Scottsdale, AZ + 12 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform Neurofibromas
Pasithea Therapeutics Corp.
- Location
- Birmingham, AL
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A proof-of Concept Study to Assess Safety and Tolerability of HM15421/GC1134A in Patients With Fabry Disease
GC Biopharma Corp
- Location
- Los Angeles, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial
Wandercraft
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Tolerability of RPE Stem Cell-derived RPE(RPESC-RPE) Transplantation in Patients With Dry Age-related Macular Degeneration (AMD)
Luxa Biotechnology, LLC
- Location
- Beverly Hills, CA + 2 other US sites
- Eligibility basics
- Ages 55+
- RecruitingPhase 1
A Study to Investigate the Safety, Tolerability, and Efficacy of BxC-I17e Single and Multiple Dose SC Injection in Patients With Moderate to Severe Atopic Dermatitis
Brexogen Inc.
- Location
- North Little Rock, AR + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients
LiveKidney.Bio
- Location
- Charleston, SC
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings
Boulder Care
- Location
- Portland, OR
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
PharmaIN
- Location
- Chandler, AZ + 8 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency
Krystal Biotech, Inc.
- Location
- Gainesville, FL + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
Safety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney Transplant
Eledon Pharmaceuticals
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–100
- RecruitingPhase 1/Phase 2
MSC EVs in Dystrophic Epidermolysis Bullosa
Aegle Therapeutics
- Location
- Phoenix, AZ + 2 other US sites
- Eligibility basics
- Ages 6 mo+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.