Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)
Noveome Biotherapeutics, formerly Stemnion
- Location
- Little Rock, AR + 7 other US sites
- Eligibility basics
- Ages 0 mo–2 mo
- RecruitingPhase 1
First in Human Study in Subjects With Obesity, But Otherwise Healthy
NeuroBo Pharmaceuticals Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
Study of NTX-2001 on Alcohol Consumption in Alcohol Use Disorder
Newleos Therapeutics, Inc.
- Location
- New Haven, CT
- Eligibility basics
- Ages 21–60
- RecruitingPhase 1
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Corneal Scars
Claris Biotherapeutics, Inc.
- Location
- Loma Linda, CA + 6 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1/Phase 2
Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma
Akouos, Inc.
- Location
- Baltimore, MD + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in…
AION Healthspan, Inc.
- Location
- Miami, FL + 1 other US site
- Eligibility basics
- Ages 35–75
- RecruitingPhase 1/Phase 2
Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD
United Therapeutics
- Location
- Chicago, IL + 1 other US site
- Eligibility basics
- Ages 40–70
- RecruitingPhase 1
A Phase 1b Study of Budoprutug in Systemic Lupus Erythematosus (SLE)
Climb Bio, Inc.
- Location
- Allen, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
Pharmacokinetics of Sulopenem Etzadroxil Plus Probenecid in Adolescents
Iterum Therapeutics, International Limited
- Location
- Little Rock, AR
- Eligibility basics
- Ages 12–17
- RecruitingPhase 1/Phase 2
A Study to Investigate the Improvement of Photosensitivity in Terms of Skin Lesions Associated With CEP Following Administration of Oral ATL-001 (Ciclopirox Oral Solution) in Participants Aged >18 Years of Age With CEP
Atlas Molecular Pharma
- Location
- Cleveland, OH
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
ModernaTX, Inc.
- Location
- Palo Alto, CA + 5 other US sites
- Eligibility basics
- Ages 1+
- RecruitingPhase 1
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
Centrexion Therapeutics
- Location
- Napa, CA
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Tenaya Therapeutics
- Location
- La Jolla, CA + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults
Shanghai World Leader Pharmaceutical Co., Ltd.
- Location
- Secaucus, NJ
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia
H. Lundbeck A/S
- Location
- Ann Arbor, MI
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury
Hope Biosciences LLC
- Location
- Houston, TX
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of ALD-102 Solution in Subjects With Alopecia Areata
Aldena Therapeutics
- Location
- Thousand Oaks, CA + 3 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1/Phase 2
A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis
Krystal Biotech, Inc.
- Location
- Pasadena, CA + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients
Opus Genetics, Inc
- Location
- Philadelphia, PA + 1 other US site
- Eligibility basics
- Ages 4+
- RecruitingPhase 1/Phase 2
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings Inc
- Location
- Miami, FL
- Eligibility basics
- Ages 18–35
- RecruitingPhase 1
A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury
Lineage Cell Therapeutics, Inc.
- Location
- La Jolla, CA
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers
Eluciderm Inc
- Location
- O'Fallon, IL + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis
ImmunAbs Inc.
- Location
- Altamonte Springs, FL + 3 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 1/Phase 2
Study of ATX-01 in Participants With DM1
ARTHEx Biotech S.L.
- Location
- Los Angeles, CA + 4 other US sites
- Eligibility basics
- Ages 18–64
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.