Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
- Location
- Doral, FL + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study of Efimosfermin Alfa in Adults With Hepatic Impairment
GlaxoSmithKline
- Location
- Rialto, CA + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
Monument Therapeutics Limited
- Location
- Irvine, CA + 14 other US sites
- Eligibility basics
- Ages 17–30
- RecruitingPhase 1/Phase 2
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
Recursion Pharmaceuticals Inc.
- Location
- St Louis, MO + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Evaluating the Safety and Tolerability of Orally Administered DF-003 in ROSAH Syndrome Patients
Shanghai Yao Yuan Biotechnology Ltd. (also known as Drug Farm)
- Location
- Durham, NC + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
SAD Study in Patients With Parkinson's Disease and Motor Fluctuations
Serina Therapeutics
- Location
- Hallandale, FL + 2 other US sites
- Eligibility basics
- Ages 40–80
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
Nkarta, Inc.
- Location
- Little Rock, AR + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)
Sangamo Therapeutics
- Location
- Scottsdale, AZ + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
Exegi Pharma, LLC
- Location
- Los Angeles, CA + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Fate Therapeutics
- Location
- Beverly Hills, CA + 15 other US sites
- Eligibility basics
- Ages 12–70
- RecruitingPhase 1
Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)
Life Biosciences Inc.
- Location
- Glendale, CA + 3 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingPhase 1/Phase 2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion
AbbVie
- Location
- Miami, FL + 11 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibility and Preliminary Efficacy of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in Patients With Parkinson's Disease.
iRegene Therapeutics Co., Ltd.
- Location
- New York, NY
- Eligibility basics
- Ages 30–75
- RecruitingPhase 1
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Krystal Biotech, Inc.
- Location
- Gainesville, FL + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes
Hua Medicine Limited
- Location
- Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Hoffmann-La Roche
- Location
- Boston, MA + 4 other US sites
- Eligibility basics
- Ages 25–65
- RecruitingPhase 1
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Portal Diabetes, Inc.
- Location
- Chula Vista, CA
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1
Achilles Tendinopathy Embolization
Joint & Vascular Institute
- Location
- Libertyville, IL
- Eligibility basics
- Ages 25–80
- RecruitingPhase 1/Phase 2
A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)
Aspa Therapeutics
- Location
- Oakland, CA + 2 other US sites
- Eligibility basics
- Up to age 2
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa
Sumitomo Pharma America, Inc.
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Rocket Pharmaceuticals Inc.
- Location
- La Jolla, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety of a Single Intravitreal Injection of RTx-021 in Patients With Stargardt Disease
Ray Therapeutics, Inc.
- Location
- Bakersfield, CA + 2 other US sites
- Eligibility basics
- Ages 16+
- RecruitingPhase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Amylyx Pharmaceuticals Inc.
- Location
- La Jolla, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Drug-Drug Interaction Study of ABP-671 in Gout Patients
Atom Therapeutics Co., Ltd
- Location
- Cary, NC
- Eligibility basics
- Ages 18–75
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.