Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
ISP-001: Sleeping Beauty Transposon-Engineered B Cells for MPS I
Immusoft of CA, Inc.
- Location
- Oakland, CA + 1 other US site
- Eligibility basics
- Ages 10+
- RecruitingPhase 1
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
AbbVie
- Location
- Carmel, IN + 4 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
AC Immune SA
- Location
- Lady Lake, FL + 3 other US sites
- Eligibility basics
- Ages 35–85
- RecruitingPhase 1
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
EicOsis Human Health Inc.
- Location
- Augusta, GA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety, Tolerability and Exploratory Efficacy of EC5026 in Parkinson's Disease (STEP Study)
EicOsis Human Health Inc.
- Location
- Sacramento, CA
- Eligibility basics
- Ages 50–80
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Participants With Mild Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Encino, CA + 3 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)
Elpida Therapeutics SPC
- Location
- Dallas, TX
- Eligibility basics
- Ages 4 mo–10
- RecruitingPhase 1/Phase 2
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)
Solid Biosciences Inc.
- Location
- Little Rock, AR + 11 other US sites
- Eligibility basics
- Ages 0 mo–17 · Men only
- RecruitingPhase 1/Phase 2
A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)
Regeneron Pharmaceuticals
- Location
- Chandler, AZ + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
UCB Biopharma SRL
- Location
- Peoria, AZ + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
Kamau Therapeutics
- Location
- Los Angeles, CA + 5 other US sites
- Eligibility basics
- Ages 12–50
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Alexion Pharmaceuticals, Inc.
- Location
- Phoenix, AZ + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study of CDX-622 in Participants With Mild to Moderate Asthma
Celldex Therapeutics
- Location
- San Francisco, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Sonoma Biotherapeutics, Inc.
- Location
- Scottsdale, AZ + 8 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study Assessing HMB-002 in Participants With Von Willebrand Disease
Hemab ApS
- Location
- Indianapolis, IN
- Eligibility basics
- Ages 16–69
- RecruitingPhase 1
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
GlaxoSmithKline
- Location
- Anniston, AL + 11 other US sites
- Eligibility basics
- Ages 65–85
- RecruitingPhase 1
Study of BHV-1400 in IgA Nephropathy
Biohaven Therapeutics Ltd.
- Location
- Farmington, CT + 13 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingEarly Phase 1
VTP-1000 in Adults With Celiac Disease
Barinthus Biotherapeutics
- Location
- Los Angeles, CA + 15 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets
Corxel Pharmaceuticals
- Location
- Las Vegas, NV + 1 other US site
- Eligibility basics
- Ages 18–55 · Women only
- RecruitingPhase 1
A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal Disease
Incyte Corporation
- Location
- Miami Lakes, FL + 1 other US site
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
R-3750 in Patients With Mild to Moderate Ulcerative Colitis
Rise Therapeutics LLC
- Location
- Valencia, CA + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
R-2487 in Patients With Rheumatoid Arthritis
Rise Therapeutics LLC
- Location
- San Diego, CA + 5 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
US Zamto-cel Autoimmune Diseases
Miltenyi Biomedicine GmbH
- Location
- Milwaukee, WI
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.