Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingEarly Phase 1
Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment
Tactile Medical
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Trial Evaluating Safety, Tolerability and Efficacy of CTX340 in Participants With Hypertension
CRISPR Therapeutics AG
- Location
- Port Orange, FL
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study)
Travere Therapeutics, Inc.
- Location
- Morrisville, NC
- Eligibility basics
- Ages 5–65
- RecruitingPhase 1/Phase 2
A Study to Evaluate KRIYA-825 (VV-14295) in Adults With Geographic Atrophy Secondary to Age-related Macular Degeneration
Kriya Therapeutics, Inc.
- Location
- Erie, PA
- Eligibility basics
- Ages 55–80
- RecruitingPhase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and…
AbbVie
- Location
- Margate, FL + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Nkarta, Inc.
- Location
- Orange, CA + 14 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity
AbbVie
- Location
- Anaheim, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)
Nuevocor Pte. Ltd.
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutations
Regeneron Pharmaceuticals
- Location
- Los Angeles, CA + 8 other US sites
- Eligibility basics
- Any age listed
- RecruitingPhase 1
Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants
Regeneron Pharmaceuticals
- Location
- Lakewood, CO + 4 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
Study of Aritinercept in Patients With Generalized Myasthenia Gravis
Aurinia Pharmaceuticals Inc.
- Location
- Pasadena, CA + 9 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
Study of BHV-1300 in Graves' Disease
Biohaven Therapeutics Ltd.
- Location
- South Gate, CA + 9 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Phase 1/2 Study of MZ-1866, an AAV-9 Gene Therapy Delivered by Intracerebroventricular Injection to Participants With Pitt Hopkins Syndrome
Mahzi Therapeutics
- Location
- Oakland, CA + 2 other US sites
- Eligibility basics
- Ages 2–25
- RecruitingPhase 1
Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese Participants
Terrestrial Bio, Inc.
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1/Phase 2
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
Ipsen
- Location
- Downey, CA + 3 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study of AZD0120 in Autoimmune Diseases
AstraZeneca
- Location
- Ann Arbor, MI + 1 other US site
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders
Cartesian Therapeutics
- Location
- Washington D.C., DC + 2 other US sites
- Eligibility basics
- Ages 12+
- RecruitingPhase 1/Phase 2
A Phase 1/2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome
MavriX Bio, LLC
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 4–50
- RecruitingPhase 1
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
Chugai Pharmaceutical
- Location
- Orange, CA + 6 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1/Phase 2
Study to Investigate the Safety of the Transplantation of Human Glial Restricted Progenitor Cells Into Subjects With Transverse Myelitis
Q Therapeutics, Inc.
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide…
Novo Nordisk A/S
- Location
- Cypress, CA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia
Apriligen, Inc.
- Location
- Stanford, CA + 1 other US site
- Eligibility basics
- Ages 2–25
- RecruitingEarly Phase 1
A Study to Investigate Safety and Efficacy of KB111 for the Treatment of Hailey-Hailey Disease
Krystal Biotech, Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 12+
- RecruitingPhase 1
Phase 1a/b Tolerability of NTR-1011 in Healthy Adults and Adult Patients With SLE and RA
Neutrolis
- Location
- Apple Valley, CA + 6 other US sites
- Eligibility basics
- Ages 18–75
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.