Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy
CytoAgents, Inc.
- Location
- Orange, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Skyline Therapeutics (US) Inc.
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 50+
- RecruitingEarly Phase 1
Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems
Weinberg Medical Physics LLC
- Location
- Houston, TX
- Eligibility basics
- Ages 65+
- RecruitingPhase 1/Phase 2
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy
Alexion Pharmaceuticals, Inc.
- Location
- Birmingham, AL + 6 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study of VV-14305 for the Treatment of Thyroid Eye Disease
Kriya Therapeutics, Inc.
- Location
- Livonia, MI + 2 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1/Phase 2
Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss
Skylark Bio Inc.
- Location
- Bethesda, MD + 3 other US sites
- Eligibility basics
- Ages 10 mo–7
- RecruitingPhase 1/Phase 2
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
Locate Bio Pty Ltd
- Location
- Fort Wayne, IN + 2 other US sites
- Eligibility basics
- Ages 22–80
- RecruitingPhase 1/Phase 2
Evaluation of Intra-articular CX-011 to Treat Moderate to Severe Pain From Knee Osteoarthritis
CarthroniX, Inc.
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 40–75
- RecruitingPhase 1
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
AstraZeneca
- Location
- Washington D.C., DC + 4 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1/Phase 2
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.
- Location
- Birmingham, AL + 15 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Eli Lilly and Company
- Location
- Maitland, FL + 4 other US sites
- Eligibility basics
- Ages 50–85
- RecruitingPhase 1
Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B
Precision BioSciences, Inc.
- Location
- Boston, MA
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia
AstraZeneca
- Location
- Glendale, CA + 5 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
4D Molecular Therapeutics
- Location
- Phoenix, AZ + 19 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Scottsdale, AZ + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory, Inc.
- Location
- Chicago, IL
- Eligibility basics
- Ages 35–70
- RecruitingPhase 1/Phase 2
AAV Gene Therapy Clinical Study in Adult Classic PKU (PHEdom)
NGGT INC.
- Location
- Orange, CA + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL952 in Adult Participants With Late-Onset Pompe Disease
Denali Therapeutics Inc.
- Location
- Irvine, CA + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Study of Amicidin-β Topical Solution for Patients With Surgical or Traumatic Wound Infections
Macro Biologics, Inc.
- Location
- Torrance, CA + 4 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingPhase 1
Phase 1 Study of C.001 in Retinal Degeneration
Cellio Therapeutics Inc
- Location
- Beverly Hills, CA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
AviadoBio Ltd
- Location
- Columbus, OH + 2 other US sites
- Eligibility basics
- Ages 30–75
- RecruitingPhase 1
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
Claris Biotherapeutics, Inc.
- Location
- Loma Linda, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the Face
Sun Pharmaceutical Industries Limited
- Location
- College Station, TX
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
Cullinan Therapeutics Inc.
- Location
- Orlando, FL + 5 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.