Study type
Smoking and vaping studies recruiting now
Tobacco research includes quit-smoking and quit-vaping programs, new cessation medicines and studies of how nicotine products affect the body.
161 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteers
A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Escalation in Young Adult ENDS Users
University of Georgia
- Location
- Athens, GA
- Eligibility basics
- Ages 18–29
- RecruitingHealthy volunteersPhase 3
Cannabis-Tobacco Co-Use Treatment Study
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Effect of Menthol on ENDS Users' Addiction and Exposure
Florida International University
- Location
- Miami, FL
- Eligibility basics
- Ages 21–35
- RecruitingHealthy volunteers
Quitxt Mobile Text Messaging Cessation Research Study
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–29
- RecruitingHealthy volunteers
Implementing a Scalable Smoke-free Home Intervention in Armenia and Georgia
George Washington University
- Location
- Washington D.C., DC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 2/Phase 3
Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology
Y. Michael Shim, MD
- Location
- Durham, NC + 1 other US site
- Eligibility basics
- Ages 18–35
- RecruitingHealthy volunteers
ACT Lung Health Intervention: Phase Two
Dana-Farber Cancer Institute
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteers
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
Abramson Cancer Center at Penn Medicine
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 3
Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Vaping and Smoking Withdrawal Project
State University of New York at Buffalo
- Location
- Buffalo, NY
- Eligibility basics
- Ages 21–50
- RecruitingHealthy volunteers
Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study
Temple University
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–25
- RecruitingHealthy volunteers
Enhancing Smoking Cessation Via Telehealth Options in Primary Care
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Studying the Health Perceptions and Social Behaviors of Graduate Students at the Ohio State University for the Development of Effective Oral Nicotine Pouch Addictive Risk Communication
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Using Novel Behavioral Economic Measures to Characterize Dual Marijuana and Tobacco Use in Young Adults
Brown University
- Location
- Providence, RI
- Eligibility basics
- Ages 18–25
- RecruitingHealthy volunteers
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
University of Oklahoma
- Location
- Tulsa, OK
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
Emory University
- Location
- Atlanta, GA
- Eligibility basics
- Ages 21–35
- RecruitingHealthy volunteersPhase 3
Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment
University of Kansas Medical Center
- Location
- Kansas City, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Take A Break - Rural
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Human Laboratory Study of the Effects of Nicotine Product Claims on Appeal, Perceptions, and Use Behavior
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Healthy Homes Study
Dartmouth-Hitchcock Medical Center
- Location
- Lebanon, NH
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Veteran Social Support for Enhancing Use of Smoking Cessation Treatment
VA Office of Research and Development
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 2
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 21–65
Who these studies look for
Most require current smoking or vaping at a set level, measured at screening. Quit studies often include counseling.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Do I have to quit to join?
Cessation studies are for people who want to quit. Other tobacco studies may ask you to keep your usual habits or switch products for a period. The listing explains which.