Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Clofutriben Pharmacokinetics in Patients With Impaired Renal Function
Sparrow Pharmaceuticals
- Location
- Orlando, FL
- Eligibility basics
- Ages 18–83
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
ViiV Healthcare
- Location
- Las Vegas, NV + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus
ChromaDex, Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
The Objective of This Phase 1 Study is to Evaluate the Food Effect of 100 mg Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fed Versus 100 mg of Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fasted Conditions in Healthy…
Aspargo Labs, Inc
- Location
- New York, NY
- Eligibility basics
- Ages 20–70 · Men only
- RecruitingHealthy volunteersPhase 1
First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young Adults
Inventprise Inc.
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersPhase 1
A First-in-Human Single and Multiple Ascending Dose Study of MT-201
Mirador Therapeutics, Inc.
- Location
- San Diego, CA
- Eligibility basics
- Ages 19–55
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of VH4011499 Compared to Placebo in Adults Without HIV
ViiV Healthcare
- Location
- Las Vegas, NV + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
Antidote Therapeutics, Inc
- Location
- Overland Park, KS
- Eligibility basics
- Ages 23–59
- RecruitingHealthy volunteersPhase 1/Phase 2
An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for Provera
Urmila DIwekar
- Location
- Houston, TX + 1 other US site
- Eligibility basics
- Ages 20–50 · Women only
- RecruitingHealthy volunteersPhase 1
A Study of IBI3032 in Healthy Participants
Fortvita Biologics (USA)Inc.
- Location
- Lenexa, KS
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Vega Therapeutics, Inc
- Location
- Los Angeles, CA + 9 other US sites
- Eligibility basics
- Ages 12–60
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever
HDT Bio
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)
Exelixis
- Location
- Orlando, FL + 1 other US site
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults
Clover Biopharmaceuticals USA, LLC
- Location
- Phoenix, AZ + 4 other US sites
- Eligibility basics
- Ages 60–85
- RecruitingHealthy volunteersPhase 1
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
Metro International Biotech, LLC
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
Ashvattha Therapeutics, Inc.
- Location
- San Francisco, CA + 2 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation
General Biophysics LLC
- Location
- Boston, MA
- Eligibility basics
- Ages 55–75
- RecruitingHealthy volunteersPhase 1
Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture
ZetrOZ, Inc.
- Location
- Trumbull, CT + 1 other US site
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Sustained Acoustic Medicine for Osteoarthritis Pain
ZetrOZ, Inc.
- Location
- Tampa, FL
- Eligibility basics
- Ages 35–85
- RecruitingHealthy volunteersPhase 1/Phase 2
Spermatogonial Differentiation Via Testicular Organoid
CellARTs Inc.
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18–60 · Men only
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study to Evaluate Safety, Tolerability and Pharmacokinetics of TIX100 in Healthy Subjects
TIXiMED, Inc.
- Location
- Chula Vista, CA
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1/Phase 2
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
Thomas Advanced Medical LLC
- Location
- Culver City, CA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1Overnight stay mentioned
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
GentiBio, Inc
- Location
- Duarte, CA + 8 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1/Phase 2Overnight stay mentioned
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
Vector Y Therapeutics
- Location
- San Diego, CA + 3 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.