Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Regeneron Pharmaceuticals
- Location
- Los Angeles, CA + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function
Pfizer
- Location
- Miami, FL + 3 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment
Daiichi Sankyo
- Location
- Miami, FL + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1/Phase 2
A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
Clearmind Medicine Inc.
- Location
- New Haven, CT + 1 other US site
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Study to Evaluate if Exposure to Drug is Impacted in Participants With Renal Insufficiency
Sun Pharmaceutical Industries Limited
- Location
- Miami Lakes, FL
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis
PRG Science & Technology Co., Ltd.
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)
Takeda
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–68
- RecruitingHealthy volunteersPhase 1
A Single- and Multiple-Ascending Dose Study of SRK-439 in Healthy Adults
Scholar Rock, Inc.
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
First-in-human Study of Orally Administered KT-579 in Healthy Adult Participants
Kymera Therapeutics, Inc.
- Location
- Lincoln, NE
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years
Centessa Pharmaceuticals (UK) Limited
- Location
- Lincoln, NE
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A First-in-Human Single and Multiple Ascending Dose Study of MT-251
Mirador Therapeutics, Inc.
- Location
- San Diego, CA
- Eligibility basics
- Ages 19–55
- RecruitingHealthy volunteersPhase 1
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults
Metro International Biotech, LLC
- Location
- Boston, MA
- Eligibility basics
- Ages 19–60
- RecruitingHealthy volunteersPhase 1
Multiple Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of KSHN001034 in Healthy Postmenopausal Female Volunteers
Kashiv BioSciences, LLC
- Location
- Miami Lakes, FL
- Eligibility basics
- Ages 45–60 · Women only
- RecruitingHealthy volunteersPhase 1
Evaluate the Pharmacokinetics, Safety, and Tolerability of NSHO-101 in Healthy Participants
Ensho Therapeutics, Inc.
- Location
- Anaheim, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Participants
Biogen
- Location
- Austin, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study of ABF-101 in Single- and Multiple-Ascending Doses
Aptabio Therapeutics, Inc.
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
A Safety Study of IVMED-85 Ophthalmic Solution in Healthy Adults
iVeena Delivery Systems, Inc.
- Location
- Memphis, TN
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersEarly Phase 1
Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
MediBeacon
- Location
- Ann Arbor, MI
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Study to Investigate HLA-G Targeted Exosome (SOB100) in Healthy Subjects
Shine-On Biomedical Co., Ltd.
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Single and Multiple Ascending Doses of NTX-253 in Healthy Participants and Participants With Stable Schizophrenia
Neurosterix
- Location
- Los Alamitos, CA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Study of MAR002 in Healthy Men
Marea Therapeutics
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–40 · Men only
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of ABBV-243 in Healthy Adults.
AbbVie
- Location
- Grayslake, IL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986521 in Healthy Participants.
Bristol-Myers Squibb
- Location
- Anaheim, CA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age
Centessa Pharmaceuticals (UK) Limited
- Location
- Lincoln, NE + 2 other US sites
- Eligibility basics
- Ages 18–80
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.