Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Phase 1, First-in-human Study of VX-433
Vertex Pharmaceuticals Incorporated
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Relative Bioavailability and Bioequivalence Study of Varegacestat in Healthy Participants
Immunome, Inc.
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control Participants
Institut de Recherches Internationales Servier (I.R.I.S.)
- Location
- Chandler, AZ + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
Eli Lilly and Company
- Location
- Los Alamitos, CA + 5 other US sites
- Eligibility basics
- Ages 45–85
- RecruitingHealthy volunteersPhase 1
A Study of Eloralintide (LY3841136) in Participants With Different Levels of Liver Damage and in Participants With Healthy Livers.
Eli Lilly and Company
- Location
- Orlando, FL + 1 other US site
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersPhase 1
A Single Dose, Phase 1 Study of JADE101 in Healthy Japanese and Chinese Participants
Jade Biosciences, Inc.
- Location
- Glendale, CA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of the Pharmacokinetics, Biodistribution and Radiation Dosimetry of [18F]MODAG-009 Positron Emission Tomography (PET) Radiotracers in Adult Healthy Volunteers
MODAG GmbH
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE/CLE Participants
DualityBio Inc.
- Location
- La Palma, CA + 4 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
Pfizer
- Location
- Cypress, CA
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Ascending Doses of ABBV-1451 Infusions and Injections in Healthy Adult Participants
AbbVie
- Location
- Grayslake, IL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)
Ensysce Biosciences
- Location
- Miami, FL
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of Mirikizumab Solution (LY3074828) in Healthy Participants
Eli Lilly and Company
- Location
- Daytona Beach, FL + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Test How BI 3000202 is Taken up in the Blood of People With and Without Liver Problems
Boehringer Ingelheim
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Study to Learn About the Safety of BIIB142 and How it is Processed in the Body of Healthy Adult Participants Aged 18 to 55 Years Old
Biogen
- Location
- Las Vegas, NV
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Study to Evaluate CAY001 in Healthy Volunteers
Cayuga Biotech, Inc.
- Location
- Fair Lawn, NJ
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
A First in Human Study of the Safety, Tolerability, and the Physiologically Based Pharmacokinetics of XFB19 in Healthy Adult Volunteers.
Xfibra, Inc.
- Location
- Knoxville, TN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Learn About a Vaccine Against E Coli in Healthy Adults
Pfizer
- Location
- Anaheim, CA + 9 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis
Sitryx Therapeutics Ltd
- Location
- Arkansas City, AR + 5 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of ENP-501 in Peanut-Allergic and Non-Allergic Participants
N-Fold, LLC
- Location
- Aurora, CO
- Eligibility basics
- Ages 14–50
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
AnnJi Pharmaceutical Co., Ltd.
- Location
- Los Alamitos, CA
- Eligibility basics
- Ages 18–55 · Men only
- RecruitingHealthy volunteersPhase 1
A Study to Learn About the Medicine Called PF-08653944 in People With and Without Reduced Liver Function
Pfizer
- Location
- Miami Lakes, FL + 2 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study on the Safety and Immune Response of a Urinary Tract Infection (UTI) Vaccine in Adults 18-64 Years of Age and Clinical Efficacy in Females 18-64 Years of Age
GlaxoSmithKline
- Location
- Lenexa, KS + 5 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of EDP-978 in Healthy Adults
Enanta Pharmaceuticals, Inc
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
First-in-Human Single and Multiple Dose of HL-400
Highlightll Pharmaceutical (USA) LLC
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.