Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Study to Learn More About the Safety of a Single Dose of BIIB144 and How it is Processed in the Body of Healthy Adult Participants Ages 18 to 55 Years Old as Compared to a Placebo
Biogen
- Location
- Las Vegas, NV
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Single and Multiple Dose Study to Evaluate Safety and Pharmacokinetics of BMS-986533 in Healthy Participants and Assessments of Food and pH Effects on Relative Bioavailability, and Drug-Drug Interaction Potential in…
Bristol-Myers Squibb
- Location
- Lincoln, NE
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With and Without Reduced Liver Function
Pfizer
- Location
- Lake Forest, CA + 2 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingHealthy volunteersPhase 1
FIH Study to Evaluate the Tolerability of PF-07832837 in Healthy Adults and Patients
Pfizer
- Location
- Anaheim, CA + 4 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Novartis Pharmaceuticals
- Location
- Scottsdale, AZ + 18 other US sites
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteersPhase 1
Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Buprenorphine/Naloxone or Methadone
Atea Pharmaceuticals, Inc.
- Location
- Hollywood, FL + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants
ViiV Healthcare
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Renal Impairment Study for Oral EC5026
EicOsis Human Health Inc.
- Location
- Sacramento, CA
- Eligibility basics
- Ages 55+
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of INCA033989 Following Subcutaneous or Intravenous Administration in Healthy Adult Participants
Incyte Corporation
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Secretome Treatment for Facial Rejuvenation
Acorn Biolabs Inc.
- Location
- Newport Beach, CA
- Eligibility basics
- Ages 30–75
- RecruitingHealthy volunteersPhase 1
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII…
Equilibra Bioscience LLC
- Location
- Los Angeles, CA + 6 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study of BBT002 in Healthy Volunteers (HVs) and in Adult Patients With Chronic Obstructive Pulmonary Disease (COPD) or Chronic Rhiosininusitis With Nasal Polyps (CRSwNP)
Bambusa Therapeutics
- Location
- Bowling Green, KY + 1 other US site
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Study to Assess How Intravenous and Subcutaneous Administrations of Risankizumab Moves Through the Body of Healthy Adult Participants
AbbVie
- Location
- Anaheim, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Safety and Efficacy of SUM-191 for Patients With Bacterial Conjunctivitis
Senju USA, Inc.
- Location
- Austin, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years
HALEON
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 6–11
- RecruitingHealthy volunteersPhase 1
The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants
Shanghai CureGene Pharmaceutical Co., Ltd.
- Location
- Miami, FL
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
Eli Lilly and Company
- Location
- Anniston, AL + 8 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
GlaxoSmithKline
- Location
- Aurora, CO + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
Alcamena Stem Cell Therapeutics
- Location
- Saint Paul, MN
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Suninflam Inc
- Location
- Tucson, AZ + 9 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies
MODAG GmbH
- Location
- New Haven, CT
- Eligibility basics
- Ages 50–80
- RecruitingHealthy volunteersPhase 1
A Trial to Compare the Pharmacokinetics of Two Presentations of Navenibart in Healthy Participants
Astria Therapeutics, Inc.
- Location
- Daytona Beach, FL + 2 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Phase 1, First-in-human Study of VX-433
Vertex Pharmaceuticals Incorporated
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Relative Bioavailability and Bioequivalence Study of Varegacestat in Healthy Participants
Immunome, Inc.
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–55
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.