Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersEarly Phase 1
Radiocaine Safety Study
Lutroo Imaging LLC
- Location
- Stanford, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of GS-4321 in Healthy Participants and Participants With Chronic Hepatitis Delta Virus
Gilead Sciences
- Location
- Anaheim, CA + 4 other US sites
- Eligibility basics
- Ages 18–69
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of OPK-88006 in Healthy and Presumed MASH Participants
OPKO Health, Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Phase 1 Trial of AMG 691 in Healthy Chinese and Japanese Volunteers
Amgen
- Location
- Las Vegas, NV
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study to Learn How the Study Medicine Called Atirmociclib is Handled by the Body in People With Normal Liver Function and Different Levels of Liver Disease
Pfizer
- Location
- Miami Lakes, FL + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Single-Dose Study of MT-201 and Concomitant Infliximab in Healthy Participants
Mirador Therapeutics, Inc.
- Location
- San Diego, CA
- Eligibility basics
- Ages 19–55
- RecruitingHealthy volunteersPhase 1
A Study of LY4178256 in Healthy Participants
Eli Lilly and Company
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease
Novartis Pharmaceuticals
- Location
- Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Bristol-Myers Squibb
- Location
- Birmingham, AL + 8 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight
Novo Nordisk A/S
- Location
- Cypress, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of…
AstraZeneca
- Location
- Glendale, CA + 3 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
Bristol-Myers Squibb
- Location
- Miami, FL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Trial to Examine if Repinatrabit is Processed Differently in Adults With Reduced Liver or Kidney Function Compared to Adults With Normal Liver and Kidney Function
Otsuka Pharmaceutical Development & Commercialization, Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
First Time in Human Study of Long Acting VH4524184 Formulations
ViiV Healthcare
- Location
- Lenexa, KS + 2 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of [18F]LY4214835 in Healthy Volunteers and Participants With Cancer
Eli Lilly and Company
- Location
- New York, NY + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Study of JPH034 in Healthy Adult Participants
J-Pharma Co., Ltd.
- Location
- Dilworth, MN
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
A Clinical Trial of MK-4082 in Healthy Participants (MK-4082-005)
Merck Sharp & Dohme LLC
- Location
- Anaheim, CA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
Amgen
- Location
- Lake Forest, CA + 1 other US site
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Safety, Tolerability and How Single Ascending Doses of ABBV-859 Moves Through the Body of Healthy Adult Participants
AbbVie
- Location
- Anaheim, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Phase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME)
Ocugen
- Location
- Deerfield Beach, FL + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Study of LY4515100 in Healthy Participants
Eli Lilly and Company
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity
Novo Nordisk A/S
- Location
- Lenexa, KS
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Safety, Tolerability, and PK of AH-008 Following Single Ascending Dose in Healthy Subjects
AnHorn Medicines Co. Ltd.
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283
GlaxoSmithKline
- Location
- Austin, TX
- Eligibility basics
- Ages 18–60
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.