Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A
Novo Nordisk A/S
- Location
- Aurora, CO + 4 other US sites
- Eligibility basics
- Ages 18–64 · Men only
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).
Merck Sharp & Dohme LLC
- Location
- Kansas City, MO + 5 other US sites
- Eligibility basics
- Ages 12–30
- RecruitingHealthy volunteersPhase 1
Safety and Pharmacokinetics of ALZ-507 in Healthy Elderly Adults
Alzheon Inc.
- Location
- Miami, FL
- Eligibility basics
- Ages 50–75
- RecruitingHealthy volunteersPhase 1
Study of Safety and PK of AZD0543 in Healthy Adults
AstraZeneca
- Location
- South Miami, FL
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS
HTIC, Inc
- Location
- Richmond, VA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Different Oral Formulations of KT-621
Kymera Therapeutics, Inc.
- Location
- Lincoln, NE
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants
AbbVie
- Location
- Maitland, FL + 3 other US sites
- Eligibility basics
- Ages 65–85
- RecruitingHealthy volunteersPhase 1/Phase 2
Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.
Sanofi
- Location
- Tempe, AZ + 15 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
Zydus Therapeutics Inc.
- Location
- Indianapolis, IN
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Phase 1 Study of Intravaginal KB15A
ZabBio Inc.
- Location
- Norfolk, VA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersPhase 1/Phase 2
First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671
Aconcagua Bio, Inc. a wholly owned subsidiary of Structure Therapeutics
- Location
- Lake Forest, CA + 2 other US sites
- Eligibility basics
- Ages 25–75
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
Insmed Incorporated
- Location
- Lake Forest, CA + 3 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.
ModeX Therapeutics, An OPKO Health Company
- Location
- Las Vegas, NV + 1 other US site
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects
Corium Innovations, Inc.
- Location
- Las Vegas, NV
- Eligibility basics
- Ages 40–75 · Women only
- RecruitingHealthy volunteersPhase 1
A First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of HMB-003 in Healthy Volunteers
Hemab ApS
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative Colitis
Ono Pharmaceutical Co., Ltd.
- Location
- Miami, FL
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Trial to Assess TEV-56286 at Different Doses in Healthy Participants
Teva Branded Pharmaceutical Products R&D LLC
- Location
- Miramar, FL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Comparative PK Assessment Study of Casdatifan in Moderate Hepatically Impaired Participants Versus Matched Participants With Normal Hepatic Function
Arcus Biosciences, Inc.
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–84
- RecruitingHealthy volunteersPhase 1
A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity
Novo Nordisk A/S
- Location
- Lenexa, KS
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study of BLKR201 in Healthy Adult Participants
Formation Bio, Inc.
- Location
- Lincoln, NE
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV
BioNTech SE
- Location
- Chicago, IL + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
A Study of the Pharmacokinetics, Biodistribution and Dosimetry of Granzyme-B Targeted [Cu-64]-Labeled PET Radiotracers in Adult Healthy Volunteers
Ratio Therapeutics, Inc.
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725
BioCryst Pharmaceuticals
- Location
- Palo Alto, CA + 4 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingHealthy volunteersPhase 1
A Study to Assess Zilucoplan Concentration in Breast Milk of Healthy Lactating Women
UCB Biopharma SRL
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18+ · Women only
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.