Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
Merck Sharp & Dohme LLC
- Location
- Madera, CA + 14 other US sites
- Eligibility basics
- Ages 2 mo–1
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects
TIXiMED, Inc.
- Location
- Chula Vista, CA
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1/Phase 2
A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older Adults
GlaxoSmithKline
- Location
- Stockbridge, GA + 2 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Pharmacokinetics and Safety of Golcadomide in Participants With Severe Renal Impairment and End-Stage Renal Disease Compared With Participants With Normal Renal Function
Bristol-Myers Squibb
- Location
- Chandler, AZ + 2 other US sites
- Eligibility basics
- Ages 18–84
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide
Kailera
- Location
- Orlando, FL + 1 other US site
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersPhase 1/Phase 2
Digital STEADI Efficacy
Friendi.fi Corporation
- Location
- Atlanta, GA
- Eligibility basics
- Ages 50+
- RecruitingHealthy volunteersPhase 1
DUVAX: A Phase 1 Alzheimer's Vaccine Study Targeting Amyloid-Beta and Tau
Nuravax, Inc.
- Location
- Miami Lakes, FL
- Eligibility basics
- Ages 40–65
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate Gepotidacin Exposure in Breast Milk of Healthy Lactating Women
GlaxoSmithKline
- Location
- Las Vegas, NV
- Eligibility basics
- Ages 18–50 · Women only
- RecruitingHealthy volunteersPhase 1
Study of Single Doses of HBS-104 in Acutely Sleep-deprived Healthy Participants
Harmony Biosciences Management, Inc.
- Location
- Eatontown, NJ
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Xencor, Inc.
- Location
- Scottsdale, AZ + 27 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study of BBT001 in Healthy Volunteers (HVs) and in Adult Patients With Atopic Dermatitis (AD)
Bambusa Therapeutics
- Location
- Irvine, CA + 2 other US sites
- Eligibility basics
- Ages 18–72
- RecruitingHealthy volunteersPhase 1
A Study to Assess Nipocalimab Concentrations in Breast Milk of Healthy Lactating Women
Janssen Research & Development, LLC
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18+ · Women only
- RecruitingHealthy volunteersPhase 1
A Study to Investigate the Safety and Pharmacokinetics of Single- and Multiple-ascending Doses of AZD4916 in Healthy Volunteers
AstraZeneca
- Location
- Glendale, CA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Assess Safety, Tolerability, and How Single and Multiple Injections or Infusions of ABBV-313 Affects the Body of Adult Participants
AbbVie
- Location
- Anaheim, CA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Safety and Pharmacokinetics of Multiple Doses Upadacitinib, Tofacitinib, and Baricitinib in Healthy Adult Volunteers
AbbVie
- Location
- Grayslake, IL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Safety and Drug Concentrations of REGN20934 in Adults With Overweight or Obesity
Regeneron Pharmaceuticals
- Location
- Glendale, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Evaluate the Effect of Vimseltinib on P-glycoprotein (P-gp) Inhibition in Healthy Male Participants
Deciphera Pharmaceuticals, LLC
- Location
- Overland Park, KS
- Eligibility basics
- Ages 18–55 · Men only
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of INS1033 in Healthy Participants
Insmed Incorporated
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC35 Injection in Participants With Obesity or Overweight
Ascletis Pharma (China) Co., Limited
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early…
Bristol-Myers Squibb
- Location
- Anaheim, CA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants
Vertex Pharmaceuticals Incorporated
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019)
Merck Sharp & Dohme LLC
- Location
- Anniston, AL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027)
Merck Sharp & Dohme LLC
- Location
- Miami Lakes, FL
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Study Comparing Two Ways of Taking Olomorasib (LY3537982) in Healthy Participants
Eli Lilly and Company
- Location
- Daytona Beach, FL
- Eligibility basics
- Ages 18–55
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.