Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
A Single and Multiple Ascending Dose Study of EPX-100 in Healthy Adult Participants
Epygenix
- Location
- Tempe, AZ
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy
Eli Lilly and Company
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease
Eli Lilly and Company
- Location
- Los Alamitos, CA + 7 other US sites
- Eligibility basics
- Ages 30–85
- RecruitingHealthy volunteersPhase 1
Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib
SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
- Location
- Miami, FL + 2 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Clinical Trial to Look at the Safety and Immune Responses of the RNA-based Vaccine BNT168 in Adults Living With or Without HIV
BioNTech SE
- Location
- Houston, TX
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Gadsden, AL + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
A Trial of Lu AH69593 in Healthy Participants
H. Lundbeck A/S
- Location
- Madison, WI
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems
Boehringer Ingelheim
- Location
- Rialto, CA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Location
- Lenexa, KS
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD3974 in Healthy Participants
AstraZeneca
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
AstraZeneca
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Comparing the Extent to Which Romosozumab (AMG 785) is Made Available in the Body When Administered as a Single SC Injection or as 2 SC Injections
Amgen
- Location
- Miami, FL
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
A Study Investigating the Safety of RO7795081 and How the Body Processes RO7795081 in People With Normal or Decreased Kidney Functions
Hoffmann-La Roche
- Location
- Miami Lakes, FL + 2 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity of V540B in Healthy Adults (V540B-002).
Merck Sharp & Dohme LLC
- Location
- Hallandale, FL + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease
Eli Lilly and Company
- Location
- Daytona Beach, FL
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersPhase 1
A Study of Eloralintide (LY3841136) in Female Participants With Obesity or Overweight
Eli Lilly and Company
- Location
- Daytona Beach, FL + 1 other US site
- Eligibility basics
- Ages 18–60 · Women only
- RecruitingHealthy volunteersPhase 1
A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise Healthy
Eli Lilly and Company
- Location
- Daytona Beach, FL + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study of LY4088044 in Healthy Participants
Eli Lilly and Company
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
Regeneron Pharmaceuticals
- Location
- Birmingham, AL + 5 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study of Navlimetostat Tablet Formulations
Bristol-Myers Squibb
- Location
- Decatur, GA
- Eligibility basics
- Ages 18–55 · Women only
- RecruitingHealthy volunteersPhase 1
Study of GS-4571 in Healthy Participants, Nondiabetic Obese Participants, and Nonobese Participants With Type 2 Diabetes Mellitus (T2DM)
Gilead Sciences
- Location
- Miami, FL + 2 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Study to Assess Potential Drug-Drug Interactions of E2086 in Healthy Participants
Eisai Inc.
- Location
- Austin, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT)
Atavistik Bio, Inc
- Location
- Phoenix, AZ + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a New Formulation of Inclisiran Containing Polysorbate 80 Compared to the Currently Marketed Formulation
Novartis Pharmaceuticals
- Location
- Lenexa, KS + 5 other US sites
- Eligibility basics
- Ages 18–60
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.