Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated
Boehringer Ingelheim
- Location
- Phoenix, AZ + 24 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).
Novartis Pharmaceuticals
- Location
- Loma Linda, CA + 10 other US sites
- Eligibility basics
- Ages 2–17
- RecruitingPhase 1/Phase 2
A Study to Evaluate Topical ATR04-484 for EGFRi-Associated Dermal Toxicity
Azitra Inc.
- Location
- Hot Springs, AR + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Safety, PK and PD of FLQ-101 in Premature Neonates
FELIQS INC.
- Location
- Austin, TX
- Eligibility basics
- Ages 0 mo–0 mo
- RecruitingPhase 1
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)
Merck Sharp & Dohme LLC
- Location
- Birmingham, AL + 20 other US sites
- Eligibility basics
- Up to age 17
- RecruitingPhase 1/Phase 2
A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A
Hoffmann-La Roche
- Location
- Orange, CA + 5 other US sites
- Eligibility basics
- Ages 18+ · Men only
- RecruitingPhase 1
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
AstraZeneca
- Location
- Jacksonville, FL + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late-Onset Pompe Disease (PROGRESS-GT LOPD)
AskBio Inc
- Location
- Irvine, CA + 4 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
First-in-human Study of UX016 in GNEM
Ultragenyx Pharmaceutical Inc
- Location
- Orange, CA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy
Hoffmann-La Roche
- Location
- Glendale, CA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Phase 1b/2 Study of IV Sarilumab in Adult With RA
Sanofi
- Location
- Centennial, CO + 11 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of LY5830966 in Participants With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I…
Ajax Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company
- Location
- Palo Alto, CA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Trial to Test the Safety and Efficacy of TEV-53408 in Participants With Vitiligo
Teva Branded Pharmaceutical Products R&D LLC
- Location
- Hot Springs, AR + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
Eli Lilly and Company
- Location
- Los Angeles, CA + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa
Incyte Corporation
- Location
- Phoenix, AZ + 15 other US sites
- Eligibility basics
- Ages 12–75
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)
Genentech, Inc.
- Location
- Peoria, AZ + 11 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A
Hoffmann-La Roche
- Location
- Sacramento, CA + 2 other US sites
- Eligibility basics
- Ages 2–59 · Men only
- RecruitingPhase 1/Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Ionis Pharmaceuticals, Inc.
- Location
- San Diego, CA + 7 other US sites
- Eligibility basics
- Ages 2–65 · Men only
- RecruitingPhase 1/Phase 2
Study to Evaluate ACDN-01 in ABCA4-related Stargardt Retinopathy (STELLAR)
Ascidian Therapeutics, Inc
- Location
- Gainesville, FL + 8 other US sites
- Eligibility basics
- Ages 12+
- RecruitingPhase 1/Phase 2
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Cabaletta Bio
- Location
- Orange, CA + 17 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingPhase 1
A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection
Innoviva Specialty Therapeutics
- Location
- Los Angeles, CA + 3 other US sites
- Eligibility basics
- Ages 0 mo–18
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
Beam Therapeutics Inc.
- Location
- Birmingham, AL + 2 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
Disc Medicine, Inc
- Location
- Birmingham, AL + 10 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- Birmingham, AL + 29 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.