Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Alnylam Pharmaceuticals
- Location
- Indianapolis, IN
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Sanofi
- Location
- Peoria, AZ + 30 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 1
A Study in Adult Males With X-linked Congenital Nephrogenic Diabetes Insipidus to Test the Effects of NDI-5001 Given for Multiple Days and to Test How NDI-5001 is Tolerated and Taken up in the Body
Otsuka Pharmaceutical Development & Commercialization, Inc.
- Location
- Jacksonville, FL + 1 other US site
- Eligibility basics
- Ages 18–55 · Men only
- RecruitingPhase 1/Phase 2
Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease
CRISPR Therapeutics AG
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or…
AbbVie
- Location
- Anniston, AL + 11 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1/Phase 2
An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease
Calico Life Sciences LLC
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 6 mo+
- RecruitingPhase 1/Phase 2
RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis
Cabaletta Bio
- Location
- Orange, CA + 16 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine)
Arbor Biotechnologies
- Location
- Rochester, MN
- Eligibility basics
- Ages 6–64
- RecruitingPhase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
AstraZeneca
- Location
- Anniston, AL + 2 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual Treatment
Kite, A Gilead Company
- Location
- Newport Beach, CA + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events
Novo Nordisk A/S
- Location
- Walnut Creek, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)
Biogen
- Location
- St Louis, MO + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
DFT383 in Pediatric Participants With Nephropathic Cystinosis
Novartis Pharmaceuticals
- Location
- Phoenix, AZ + 5 other US sites
- Eligibility basics
- Ages 2–5
- RecruitingPhase 1
Obe-cel in Refractory Progressive Forms of Multiple Sclerosis
Autolus Limited
- Location
- Palo Alto, CA
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1/Phase 2
An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)
Complement Therapeutics
- Location
- Carmel, IN + 3 other US sites
- Eligibility basics
- Ages 55+
- RecruitingPhase 1
An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis
Hoffmann-La Roche
- Location
- Chula Vista, CA + 2 other US sites
- Eligibility basics
- Ages 18–60
- RecruitingPhase 1
Resmetirom in Patients With MASH and HFpEF
Madrigal Pharmaceuticals, Inc.
- Location
- Peoria, AZ + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Semaglutide Medication
Novo Nordisk A/S
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Explore the Tissue Level Effects of Remibrutinib in Adults With Moderate to Severe HS
Novartis Pharmaceuticals
- Location
- Mayfield Heights, OH
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication
Novo Nordisk A/S
- Location
- Glendale, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With…
Cabaletta Bio
- Location
- Redwood City, CA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Learn About How Changing Therapy From Emicizumab to Marstacimab Affects People With the Severe Hemophilia A.
Pfizer
- Location
- Los Angeles, CA + 2 other US sites
- Eligibility basics
- Ages 12–74 · Men only
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
BlueRock Therapeutics
- Location
- Los Angeles, CA + 4 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Safety and Efficacy of Soquelitinib in Adults With Hidradenitis Suppurativa
Corvus Pharmaceuticals, Inc.
- Location
- Bowling Green, KY + 8 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.