Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersEarly Phase 1
R01.Aim 2.Study 1: IsoReach
Shirley Ryan AbilityLab
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Imaging Synapses With [11C] UCB-J in the Human Brain
Davidzon, Guido, M.D.
- Location
- Palo Alto, CA + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Promoting Playfulness
Florida Gulf Coast University
- Location
- Fort Myers, FL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Monoferric for Prenatal Iron Deficiency
Oregon Health and Science University
- Location
- Portland, OR
- Eligibility basics
- Ages 18–65 · Women only
- RecruitingHealthy volunteersPhase 1
CogT pSOPT Intervention Study
Stanford University
- Location
- Palo Alto, CA
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1/Phase 2
Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome
University of Louisville
- Location
- Louisville, KY
- Eligibility basics
- Ages 18–65 · Women only
- RecruitingHealthy volunteersPhase 1/Phase 2
Hyperpolarized Xenon-129 MR Imaging of the Lung
University of Virginia
- Location
- Charlottesville, VA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Sacramento Pediatric Gastroenterology
- Location
- Sacramento, CA
- Eligibility basics
- Ages 0 mo–40
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Encoded Therapeutics
- Location
- San Francisco, CA + 9 other US sites
- Eligibility basics
- Ages 6 mo–17
- RecruitingPhase 1
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Verve Therapeutics, Inc.
- Location
- Garden Grove, CA + 4 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- La Jolla, CA + 7 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
Bristol-Myers Squibb
- Location
- Denver, CO
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study About the Safety of a Single ASP2020 Eye Injection and if it Helps People With Vision Loss From Stargardt-type Eye Conditions
Astellas Institute for Regenerative Medicine
- Location
- Phoenix, AZ + 3 other US sites
- Eligibility basics
- Ages 6+
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Two Formulations of ASC36 Injection in Participants With Obesity or Overweight
Ascletis Pharma (China) Co., Limited
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC36 Tablets for Oral Use in Adult Participants With Obesity or Overweight
Ascletis Pharma (China) Co., Limited
- Location
- South Miami, FL
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Cullinan Therapeutics Inc.
- Location
- Avondale, AZ + 10 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage
Astellas Pharma Global Development, Inc.
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Phoenix, AZ + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of DSP-1083 Into Subjects With Parkinson's Disease
Sumitomo Pharma America, Inc.
- Location
- La Jolla, CA + 2 other US sites
- Eligibility basics
- Ages 40–72
- RecruitingPhase 1
Safety and Preliminary Efficacy of ULSC in Facioscapulohumeral Muscular Dystrophy (FSHD)
Restem, LLC.
- Location
- Palo Alto, CA
- Eligibility basics
- Ages 15+
- RecruitingPhase 1
Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
Consano Bio
- Location
- Fernandina Beach, FL + 1 other US site
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM)
Affinia Therapeutics
- Location
- Miami, FL + 3 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
Precision BioSciences, Inc.
- Location
- Little Rock, AR + 1 other US site
- Eligibility basics
- Ages 2–7 · Men only
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.