Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Assessment of [18F]-Fluorocellobiose ([18F]FCB) Pharmacokinetics in Healthy Volunteers and Subjects With Invasive Mold Infections
National Institutes of Health Clinical Center (CC)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteersEarly Phase 1
Entire-body PET Scans for Multiple Sclerosis
Brain Health Alliance
- Location
- Ladera Ranch, CA
- Eligibility basics
- Ages 25–55
- RecruitingHealthy volunteersEarly Phase 1
Testosterone and Neural Function in Men With Spinal Cord Injury
VA Office of Research and Development
- Location
- The Bronx, NY
- Eligibility basics
- Ages 18–80 · Men only
- RecruitingHealthy volunteersPhase 1
The Effects of Cannabidiol on the Driving Performance of Healthy Adults by Dose and Sex
West Virginia University
- Location
- Morgantown, WV
- Eligibility basics
- Ages 18–30
- RecruitingHealthy volunteersEarly Phase 1
Pharmacological Modulation of Brain Oscillations in Memory Processing
University of Texas Southwestern Medical Center
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Effect of Neural Constraints on Movement in Stroke
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Effects of Sirolimus on Asymptomatic ApoE4 Carriers
University of Missouri-Columbia
- Location
- Columbia, MO
- Eligibility basics
- Ages 45–65 · Women only
- RecruitingHealthy volunteersPhase 1/Phase 2
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Baylor College of Medicine
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
University of Utah
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 25–65
- RecruitingHealthy volunteersPhase 1
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Temporal Interference for Thalamocortical Activity and Network Modulation
University of Wisconsin, Madison
- Location
- Madison, WI
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
David D'Alessio, M.D.
- Location
- Durham, NC
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1/Phase 2
Psilocybin Efficacy With or Without Pimavanserin Pretreatment
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1
Evaluation of [11C]ZTP-1 to Image PDE4B
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–101
- RecruitingHealthy volunteersPhase 1
The Gut - PRO Study
University of Wisconsin, Madison
- Location
- Madison, WI
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
PET Imaging of Noradrenergic Transmission in the Brain
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–105
- RecruitingHealthy volunteersPhase 1
Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
Christopher D. Verrico
- Location
- Houston, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
: Vascular Function in Health and Disease
D. Walter Wray
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
Sumithira Vasu
- Location
- Columbus, OH
- Eligibility basics
- Ages 1–85
- RecruitingHealthy volunteersPhase 1
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersEarly Phase 1
HA35 Acute Alcohol Study
The Cleveland Clinic
- Location
- Cleveland, OH
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase I-II Study Investigating the All-Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 12+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.