Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Dopamine and Sensorimotor Function in Stuttering
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Safety of Anal Curcumin
Lisa Flowers
- Location
- Atlanta, GA + 1 other US site
- Eligibility basics
- Ages 30+
- RecruitingHealthy volunteersEarly Phase 1
Light Therapy for Obsessive-compulsive Disorder (OCD)
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 17–35
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
Kara Chew
- Location
- Los Angeles, CA + 1 other US site
- Eligibility basics
- Ages 40–64
- RecruitingHealthy volunteersPhase 1
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–101
- RecruitingHealthy volunteersPhase 1
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Glutamatergic Mechanisms: Aim2
New York State Psychiatric Institute
- Location
- New York, NY
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Motorized Prostheses for Lower-limb Amputees
University of Utah
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma
Abramson Cancer Center at Penn Medicine
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
The RECAP2 Study: Midazolam and Psilocybin
University of Wisconsin, Madison
- Location
- Madison, WI
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 30+
- RecruitingHealthy volunteersPhase 1
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 50+
- RecruitingHealthy volunteersEarly Phase 1
Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 18–99
- RecruitingHealthy volunteersEarly Phase 1
Repeated CBD Administration and Cannabis Outcomes
Hannah Harris
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 14–89 · Women only
- RecruitingHealthy volunteersPhase 1
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
National Eye Institute (NEI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 5–120
- RecruitingHealthy volunteersPhase 1
Administering NMT to Reestablish Infant Nasal Microbiome Diversity Following Intranasal Mupirocin Treatment
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 0 mo–60
- RecruitingHealthy volunteersPhase 1/Phase 2
Chronic Lung Allograft Dysfunction MRI Study
Sean Fain
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Atlanta, GA + 6 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
18F-FTHA IMAGING OF THE INTESTINAL AND CENTRAL LYMPHATIC SYSTEM
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Retina is a Marker for Cerebrovascular Heath
Mayo Clinic
- Location
- Jacksonville, FL
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.