Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Testing RG1-VLP Vaccine to Prevent HPV-related Cancers
National Cancer Institute (NCI)
- Location
- Madison, WI
- Eligibility basics
- Ages 18–60 · Women only
- RecruitingHealthy volunteersPhase 1
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–90
- RecruitingHealthy volunteersPhase 1
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Jennifer Mitchell
- Location
- San Francisco, CA
- Eligibility basics
- Ages 50–85
- RecruitingHealthy volunteersPhase 1
Evaluation of Oral THC and CBD in Men and Women
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersPhase 1
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
High Potency Cannabis: Acute and Protracted Effects
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersEarly Phase 1
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
University of Texas Southwestern Medical Center
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
The Pharmacokinetics of a Hemp-Based Topical Product
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Alpelisib Challenge Test (ACT)
Columbia University
- Location
- New York, NY
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersEarly Phase 1
Zinc Oxide Versus Petrolatum Following Skin Surgery
Melissa Pugliano-Mauro
- Location
- Pittsburgh, PA, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Volunteer - Dosimetry Study)
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
University of Florida
- Location
- Gainesville, FL
- Eligibility basics
- Up to age 50
- RecruitingHealthy volunteersPhase 1
Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation
University of Chicago
- Location
- Chicago, IL + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Birmingham, AL + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Safety and Tolerability Study of VVZ-2471 in Healthy Volunteers
Virginia Commonwealth University
- Location
- Richmond, VA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
University of South Florida
- Location
- Tampa, FL
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersEarly Phase 1
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
KABAWIL: Reducing Intersectional Stigmas
University of Washington
- Location
- Seattle, WA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Aurora, CO + 4 other US sites
- Eligibility basics
- Any age listed
- RecruitingHealthy volunteersPhase 1
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Columbia University
- Location
- New York, NY
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–60
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.