Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersEarly Phase 1
JIT: Effect of Pain on DT in TMD
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersEarly Phase 1
Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy
Texas Tech University Health Sciences Center
- Location
- Lubbock, TX
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Smart Olfaction App to Reduce Relapse
University of Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Utah
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Breathing for Two: Inspiratory Muscle Strength Training for Supporting Healthy Blood Pressure in Pregnancy
University of Arizona
- Location
- Tucson, AZ
- Eligibility basics
- Ages 18–55 · Women only
- RecruitingHealthy volunteersEarly Phase 1
Imaging CRF X NOP Interactions in CUD
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Aging and Task-specific Training to Reduce Falls
University of Illinois at Chicago
- Location
- Chicago, IL
- Eligibility basics
- Ages 60–90
- RecruitingHealthy volunteersPhase 1
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Location
- Birmingham, AL + 1 other US site
- Eligibility basics
- Ages 19+ · Women only
- RecruitingHealthy volunteersEarly Phase 1
rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance
Northwestern University
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+ · Men only
- RecruitingHealthy volunteersPhase 1
COES: Curing Order Effects on Sealants
University of Southern California
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 5–14
- RecruitingHealthy volunteersPhase 1
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Sleep Disordered Breathing With Opioid Use
VA Office of Research and Development
- Location
- Detroit, MI
- Eligibility basics
- Ages 18–89
- RecruitingHealthy volunteersEarly Phase 1
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 22–33
- RecruitingHealthy volunteersEarly Phase 1
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Nationwide Children's Hospital
- Location
- Cincinnati, OH + 1 other US site
- Eligibility basics
- Ages 1–21
- RecruitingHealthy volunteersPhase 1
Comparative Evaluation of Nicotine Analogs
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
Liver Adiposity Effects on Pediatric Statin
Children's Mercy Hospital Kansas City
- Location
- Kansas City, MO
- Eligibility basics
- Ages 8–21
- RecruitingHealthy volunteersPhase 1/Phase 2
Classroom Break, Cognition, and Fitness in Elementary School Children
Purdue University
- Location
- Royal Center, IN
- Eligibility basics
- Ages 8–12
- RecruitingHealthy volunteersPhase 1/Phase 2
MTOR Inhibitors in Older Adults
University of Texas Southwestern Medical Center
- Location
- Dallas, TX
- Eligibility basics
- Ages 65–80
- RecruitingHealthy volunteersEarly Phase 1
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
University of Nebraska
- Location
- Omaha, NE
- Eligibility basics
- Ages 50–75
- RecruitingHealthy volunteersEarly Phase 1
Measuring Acute Drug Demand in Humans
University of Maryland, Baltimore
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Psilocybin for Prolonged Grief Disorder
University of Virginia
- Location
- Charlottesville, VA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Gait Adaptation Study
Rutgers, The State University of New Jersey
- Location
- Newark, NJ
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
Spinal Cord Associative Plasticity Study
Columbia University
- Location
- New York, NY + 2 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Cannabis and Opioid Use Disorder
Shanna Babalonis, PhD
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–55
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.