Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 27, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
Behavioral Economic Attributes of Recreation
Rush University Medical Center
- Location
- Chicago, IL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
Deepak C. D'Souza
- Location
- West Haven, CT
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1
AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Post-operative Urinary Retention (POUR) Following Thoracic Surgery
Hackensack Meridian Health
- Location
- Hackensack, NJ
- Eligibility basics
- Ages 50+ · Men only
- RecruitingHealthy volunteersPhase 1
Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersEarly Phase 1
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
University of Texas at Austin
- Location
- Austin, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Suvorexant and Alcohol
William Stoops
- Location
- Lexington, KY
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersEarly Phase 1
Cocaine and Pentoxifylline (BED IN 47)
William Stoops
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Exercise as an Immune Adjuvant for Allogeneic Cell Therapies
University of Arizona
- Location
- Tucson, AZ
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersPhase 1
Controlled Human Infection Study of Orally Administered Trichuris Trichiura Eggs in Naïve Adults
George Washington University
- Location
- Washington D.C., DC + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersEarly Phase 1
Attentional Mechanisms in SCD
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 55+
- RecruitingHealthy volunteersEarly Phase 1
Effects of a Hemp Product on the Pharmacokinetics and Pharmacodynamics of Clopidogrel
Washington State University
- Location
- Spokane, WA
- Eligibility basics
- Ages 21–64
- RecruitingHealthy volunteersEarly Phase 1
Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach
Washington State University
- Location
- Spokane, WA
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersEarly Phase 1
Brain Mechanisms Supporting Cannabis-induced Pain Relief
University of California, San Diego
- Location
- La Jolla, CA
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersEarly Phase 1
Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints
Washington State University
- Location
- Spokane, WA
- Eligibility basics
- Ages 21–45
- RecruitingHealthy volunteersEarly Phase 1
Imaging CRF X NOP Interactions in Alcohol Use Disorder
Rajesh Narendran
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies
St. Jude Children's Research Hospital
- Location
- Memphis, TN
- Eligibility basics
- Up to age 21
- RecruitingHealthy volunteersPhase 1
Hormones, Outcomes, and Pain Pathways in Exercise Study
University of Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18–60 · Women only
- RecruitingHealthy volunteersEarly Phase 1
RESTOR: PK/PD mTORi Inhibition in Older Adults
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX
- Eligibility basics
- Ages 65–90
- RecruitingHealthy volunteersEarly Phase 1
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
Dana-Farber Cancer Institute
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
The Effects of Dietary Supplementation on Serum Protein Glycosylation
University of California, Davis
- Location
- Sacramento, CA
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Rapalog Pharmacology (RAP PAC) Study
University of Wisconsin, Madison
- Location
- Madison, WI
- Eligibility basics
- Ages 55–89
- RecruitingHealthy volunteersPhase 1
Behavioral Pharmacology of Orally Administered THC and D-limonene
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–55
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.