Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
University of California, San Diego
- Location
- San Diego, CA
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Impulsivity Domains and Subjective Response
Jessica Weafer
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 21–25
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Saci Nivo Rela for TNBC
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)
University of California, Davis
- Location
- Sacramento, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Study of KM-023 in Healthy Volunteers and Patients With Olmsted Syndrome.
Orvida Pharma (formerly Kamari Pharma)
- Location
- Chicago, IL
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Sensory Feedback and Hand Motor Adaptation
The Catholic University of America
- Location
- Washington D.C., DC
- Eligibility basics
- Ages 20–70
- RecruitingHealthy volunteersEarly Phase 1
Ketamine and Propofol NeuroImaging
Keith M Vogt
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersPhase 1
Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
Baylor College of Medicine
- Location
- Washington D.C., DC
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Sympatholysis in Chronic Kidney Disease
Emory University
- Location
- Decatur, GA
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1/Phase 2
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersEarly Phase 1
Weekly Isotretinoin vs Tetracycline for Moderate Acne
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 12+
- RecruitingHealthy volunteersPhase 1
Sex Differences in the Response to Abstinence From Alcohol.
Indiana University
- Location
- Indianapolis, IN
- Eligibility basics
- Ages 21–35
- RecruitingHealthy volunteersPhase 1
Macrophage Regulation of Ozone-Induced Lung Inflammation
Robert Tighe, MD
- Location
- Durham, NC
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse
Fred Hutchinson Cancer Center
- Location
- Seattle, WA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
ACT for Individuals With MNCD and Their Care Partners
Texas Tech University
- Location
- Lubbock, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
University of Colorado, Denver
- Location
- Aurora, CO
- Eligibility basics
- Ages 12–80
- RecruitingHealthy volunteersPhase 1
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1
Restoration of Antibiotics Related Infant Microbiota Perturbations by Autologous Fecal Transplant
Rutgers, The State University of New Jersey
- Location
- New Brunswick, NJ
- Eligibility basics
- Ages 1 mo–4
- RecruitingHealthy volunteersEarly Phase 1
The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma
MCPHS University
- Location
- Worcester, MA
- Eligibility basics
- Ages 50–100
- RecruitingHealthy volunteersPhase 1
First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Overland Park, KS
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersPhase 1
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
Vanderbilt University Medical Center
- Location
- Nashville, TN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Mario Castro, MD, MPH
- Location
- Kansas City, KS
- Eligibility basics
- Ages 3+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.