Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersEarly Phase 1
Combination of Tagraxofusp With Pacritinib in Patients With Intermediate-1 or Higher Myelofibrosis, Who Have Had Prior Therapy With the Approved JAK Inhibitors or in Which Therapy With the Approved JAK Inhibitors is Not…
University of Kansas Medical Center
- Location
- Fairway, KS
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 40–99
- RecruitingHealthy volunteersEarly Phase 1
Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
University of Virginia
- Location
- Charlottesville, VA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging CCR2 in Lung Inflammation
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Cannabis Use, Cognition, and the Endocannabinoid System in HIV
University of California, San Diego
- Location
- San Diego, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
University of Florida
- Location
- Gainesville, FL
- Eligibility basics
- Ages 45–85
- RecruitingHealthy volunteersEarly Phase 1
Quadriceps Motor Unit Adaptation to Simulated Knee Injury
University of Central Florida
- Location
- Orlando, FL
- Eligibility basics
- Ages 18–30
- RecruitingHealthy volunteersPhase 1
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Yale University
- Location
- West Haven, CT
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Cannabidiol Effects on Learning and Anxiety
University of Connecticut
- Location
- Storrs, CT
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1/Phase 2
Lipomas Treated With Subcutaneous Injections of Cooled or Warmed Sodium Chloride
West Virginia University
- Location
- Morgantown, WV
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Mental Health in Veterans and Families After Group Therapies
Soul Medicine Institute
- Location
- Santa Rosa, CA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
University of Pennsylvania
- Location
- New Haven, CT + 2 other US sites
- Eligibility basics
- Ages 40–85
- RecruitingHealthy volunteersPhase 1/Phase 2
FACE Phase II (a Stage II Trial)
Stanford University
- Location
- Palo Alto, CA
- Eligibility basics
- Ages 60–89
- RecruitingHealthy volunteersPhase 1/Phase 2
Clinical Trials of Multivalent Opioid Vaccine Components
New York State Psychiatric Institute
- Location
- Eatontown, NJ
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Neural Response to Inflammatory Challenge in Major Depressive Disorder
Laureate Institute for Brain Research, Inc.
- Location
- Tulsa, OK
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Microelectrode Recordings From the Vagus Nerve in Awake Humans
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteersPhase 1/Phase 2
Rh-PDGF vs EMD for Treatment of Intra-bony Defects
Nova Southeastern University
- Location
- Davie, FL
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion
Jose Cancelas
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
Icahn School of Medicine at Mount Sinai
- Location
- New York, NY + 2 other US sites
- Eligibility basics
- Ages 18–90
- RecruitingHealthy volunteersEarly Phase 1
A Study of Niacin Regulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Regional Lipolysis Insulin Regulation
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Effect of Cannabis on E-Cigarette Use Behavior
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.