Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
E-CEL UVEC Treatment for Anal Fissures
Weill Medical College of Cornell University
- Location
- New York, NY
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Stimulating After Recovery From Traumatic Brain Injury
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
Duke University
- Location
- Durham, NC
- Eligibility basics
- Ages 18–21
- RecruitingHealthy volunteersEarly Phase 1
Remimazolam NeuroImaging
Keith M Vogt
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–59
- RecruitingHealthy volunteersPhase 1
MDMA-Assisted Therapy for Mental Healthcare Providers
Rachel Yehuda
- Location
- New York, NY
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging of MMP Activation in AAA: Clinical Component
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Daniel Claassen
- Location
- Nashville, TN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
SV2A Density Cannabis Use Disorder
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersEarly Phase 1
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
Northwell Health
- Location
- Manhasset, NY
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersEarly Phase 1
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Stanford University
- Location
- Stanford, CA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS
City of Hope Medical Center
- Location
- Duarte, CA + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Investigation of Psychedelic Effects in Psychoactive Substances
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 25–55
- RecruitingHealthy volunteersPhase 1
Alternation in the Human Microbiome With Commonly Used Topical Medications
University of California, Davis
- Location
- Sacramento, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome
Queen's Medical Center
- Location
- Honolulu, HI
- Eligibility basics
- Ages 18–54 · Women only
- RecruitingHealthy volunteersPhase 1
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Children's Hospital of Philadelphia
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
The Use of Near-Infrared Fluorescence Cholangiography With Indocyanine Green (ICG) in the Work Up of Neonatal Cholestasis
University of Alabama at Birmingham
- Location
- Birmingham, AL
- Eligibility basics
- Ages 0 mo–4 mo
- RecruitingHealthy volunteersPhase 1/Phase 2
Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults
Children's Hospital Medical Center, Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 6+
- RecruitingHealthy volunteersEarly Phase 1
Effect of C-peptide on Hypoglycemic Counterregulation
University of Cincinnati
- Location
- Cincinnati, OH
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteersPhase 1
Acute Effects of Oral Nicotine Pouches
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Localizing Epileptic Networks Using MRI and iEEG
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.