Core: healthy volunteers
Phase 1 clinical trials recruiting now
Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
934 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Spinal Cord Injury Neuroprotection With Glyburide
Francis Farhadi
- Location
- Lexington, KY
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersEarly Phase 1
Vascular Effects of High-Salt After Preeclampsia
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–45 · Women only
- RecruitingHealthy volunteersPhase 1
Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Anxiety During Abstinence in AUD
Columbia University
- Location
- New York, NY
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersEarly Phase 1
Intermittent Visual Perturbations to Enhance Balance Training
University of Florida
- Location
- Gainesville, FL
- Eligibility basics
- Ages 18–89
- RecruitingHealthy volunteersPhase 1/Phase 2
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
National Heart, Lung, and Blood Institute (NHLBI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 2–80
- RecruitingHealthy volunteersEarly Phase 1
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Beth Israel Deaconess Medical Center
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1/Phase 2
Molecular Imaging of NET Using [C-11]MRB-PET in MS
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer
Texas Christian University
- Location
- Fort Worth, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersEarly Phase 1
Insulin Regulation of Lipolysis and Lipolysis Proteins
Mayo Clinic
- Location
- Rochester, MN
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Identification of Critical Thermal Environments for Aged Adults
Penn State University
- Location
- University Park, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Biologic Therapy to Prevent Osteoarthritis After ACL Injury
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18–35
- RecruitingHealthy volunteersPhase 1/Phase 2
Linaclotide for Colonoscopy Bowel Prep
University of Florida
- Location
- Gainesville, FL
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
PET Image in PAH Patients
Stephen Y. Chan
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Home-based Vision Therapy
VA Office of Research and Development
- Location
- Cleveland, OH
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Effect of Cannabis on Cigarette Use Behavior
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
University of Florida
- Location
- Gainesville, FL
- Eligibility basics
- Ages 21–45
- RecruitingHealthy volunteersPhase 1/Phase 2
Curcumin and Retinal Study
Texas Tech University Health Sciences Center
- Location
- Lubbock, TX
- Eligibility basics
- Ages 40–89
- RecruitingHealthy volunteersEarly Phase 1
Assessment of Synaptic Density in MS
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Age-dependent Effects of Smoked and Oral Delta-9-THC
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent…
City of Hope Medical Center
- Location
- Duarte, CA
- Eligibility basics
- Up to age 75
- RecruitingHealthy volunteersPhase 1
PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy
Michael Randall
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.